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  1. Research

    CDC42-interacting protein 4 promotes metastasis of nasopharyngeal carcinoma by mediating invadopodia formation and activating EGFR signaling

    Nasopharyngeal carcinoma (NPC) is a common malignancy in Southern China and Southeast Asia. In this study, we investigated the functional and molecular mechanisms by which CDC42-interacting protein 4 (CIP4) in...

    Dong-Fang Meng, Ping Xie, Li-Xia Peng, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Xing Lv, Lin Wang, Ming-Yuan Chen, Hai-Qiang Mai, Ling Guo, Xiang Guo, Li-Sheng Zheng, Li Cao, Jun-Ping Yang, Meng-Yao Wang…

    Journal of Experimental & Clinical Cancer Research 2017 36:21

    Published on: 28 January 2017

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2017 36:33

  2. Research

    HERV-K activation is strictly required to sustain CD133+ melanoma cells with stemness features

    Melanoma is a heterogeneous tumor in which phenotype-switching and CD133 marker have been associated with metastasis promotion and chemotherapy resistance. CD133 positive (CD133+) subpopulation has also been s...

    Ayele Argaw-Denboba, Emanuela Balestrieri, Annalucia Serafino, Chiara Cipriani, Ilaria Bucci, Roberta Sorrentino, Ilaria Sciamanna, Alessandra Gambacurta, Paola Sinibaldi-Vallebona and Claudia Matteucci

    Journal of Experimental & Clinical Cancer Research 2017 36:20

    Published on: 26 January 2017

  3. Research

    Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN/Akt signaling pathway in gastric cancer

    Gastric cancer is one of the major causes of cancer-related mortality worldwide. Most of patients presenting with inoperable gastric cancers rely on systemic chemotherapy for prolongation of survival. Doxorubi...

    Jiahui Xu, Deying Liu, Huilin Niu, Guifang Zhu, Yangwei Xu, Danli Ye, Jian Li and Qingling Zhang

    Journal of Experimental & Clinical Cancer Research 2017 36:19

    Published on: 26 January 2017

  4. Research

    MIF/CD74 axis is a target for novel therapies in colon carcinomatosis

    Strategies aimed at obtaining a complete cytoreduction are needed to improve long-term survival for patients with colorectal cancer peritoneal carcinomatosis (CRC-pc).

    Fabio Bozzi, Angela Mogavero, Luca Varinelli, Antonino Belfiore, Giacomo Manenti, Claudio Caccia, Chiara C. Volpi, Galina V. Beznoussenko, Massimo Milione, Valerio Leoni, Annunziata Gloghini, Alexandre A. Mironov, Ermanno Leo, Silvana Pilotti, Marco A. Pierotti, Italia Bongarzone…

    Journal of Experimental & Clinical Cancer Research 2017 36:16

    Published on: 23 January 2017

  5. Research

    Regulation of TRIM24 by miR-511 modulates cell proliferation in gastric cancer

    Increasing evidence highlights the important roles of tripartite motif containing 24 (TRIM24) in tumor initiation and malignant progression in many tumors, including gastric cancer (GC). Although TRIM24 expres...

    Ziling Fang, Ling Zhang, Quan Liao, Yi Wang, Feng Yu, Miao Feng, Xiaojun Xiang and Jianping Xiong

    Journal of Experimental & Clinical Cancer Research 2017 36:17

    Published on: 23 January 2017

  6. Research

    Pro-inflammation NF-κB signaling triggers a positive feedback via enhancing cholesterol accumulation in liver cancer cells

    Hepatocellular carcinoma (HCC) develops in a complex microenvironment characterized by chronic inflammation. In recent years, cholesterol metabolic abnormalities have been implicated the importance in cancer c...

    Mingyan He, Wenhui Zhang, Yinying Dong, Lishun Wang, Tingting Fang, Wenqing Tang, Bei Lv, Guanglang Chen, Biwei Yang, Peixin Huang and Jinglin Xia

    Journal of Experimental & Clinical Cancer Research 2017 36:15

    Published on: 18 January 2017

  7. Research

    The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer

    Pancreatic cancer is a lethal malignancy that frequently acquires resistance to conventional chemotherapies often associated with overexpression of inhibitors of apoptosis proteins (IAPs). We have recently des...

    Yassar M. Hashim, Suwanna Vangveravong, Narendra V. Sankpal, Pratibha S. Binder, Jingxia Liu, S. Peter Goedegebuure, Robert H. Mach, Dirk Spitzer and William G. Hawkins

    Journal of Experimental & Clinical Cancer Research 2017 36:14

    Published on: 17 January 2017

  8. Review

    Deptor: not only a mTOR inhibitor

    Deptor is an important protein that belongs to the mTORC1 and mTORC2 complexes, able to interact with mTOR and to inhibit its kinase activity. As a natural mTOR inhibitor, Deptor is involved in several molecul...

    Valeria Catena and Maurizio Fanciulli

    Journal of Experimental & Clinical Cancer Research 2017 36:12

    Published on: 13 January 2017

  9. Research

    Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes tumorigenesis and metastasis by targeting miR-199a/b-5p in hepatocellular carcinoma

    Hepatocellular carcinoma (HCC) is third leading cause of cancer-related death globally. Evidence suggest that long non-coding RNAs (lncRNAs) have emerged as key regulators of tumorigenesis and metastasis in HC...

    Tian Lan, Weijie Ma, Zhenfei Hong, Long Wu, Xi Chen and Yufeng Yuan

    Journal of Experimental & Clinical Cancer Research 2017 36:11

    Published on: 10 January 2017

  10. Research

    Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation

    The ubiquitin-ligase Fbw7 acts as a tumor suppressor, targeting lots of proto-oncogenes for proteolysis. However, the exact role of Fbw7 in diffuse large B-cell lymphoma (DLBCL) development remains unclear.

    Su Yao, Fangping Xu, Yu Chen, Yan Ge, Fen Zhang, Huijie Huang, Li Li, Danyi Lin, Xinlan Luo, Jie Xu, Donglan Luo, Xiaolan Zhu and Yanhui Liu

    Journal of Experimental & Clinical Cancer Research 2017 36:10

    Published on: 10 January 2017

  11. Research

    FGF19/FGFR4 signaling contributes to the resistance of hepatocellular carcinoma to sorafenib

    Sorafenib, a multi-kinase inhibitor, is used as a standard therapy for advanced hepatocellular carcinoma (HCC). However, complete remission has not been achieved and the molecular basis of HCC resistance to so...

    Lixia Gao, Xuli Wang, Yaoliang Tang, Shuang Huang, Chien-An Andy Hu and Yong Teng

    Journal of Experimental & Clinical Cancer Research 2017 36:8

    Published on: 9 January 2017

  12. Research

    Motility of glioblastoma cells is driven by netrin-1 induced gain of stemness

    Glioblastoma is an untreatable brain cancer. The tumors contain a population of stem-like cells which are highly invasive and resistant to therapies. These cells are the main reason for the lethality of gliobl...

    Irene Ylivinkka, Harri Sihto, Olli Tynninen, Yizhou Hu, Aki Laakso, Riku Kivisaari, Pirjo Laakkonen, Jorma Keski-Oja and Marko Hyytiäinen

    Journal of Experimental & Clinical Cancer Research 2017 36:9

    Published on: 9 January 2017

  13. Research

    Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma

    Many cancers including head and neck squamous cell carcinoma (HNSCC) are characterized by a metabolic rewiring with increased glucose uptake and lactate production, termed as aerobic glycolysis. Targeting aero...

    Hui-Min Li, Jie-Gang Yang, Zhuo-Jue Liu, Wei-Ming Wang, Zi-Li Yu, Jian-Gang Ren, Gang Chen, Wei Zhang and Jun Jia

    Journal of Experimental & Clinical Cancer Research 2017 36:7

    Published on: 7 January 2017

  14. Research

    Short-term early exposure to lapatinib confers lifelong protection from mammary tumor development in MMTV-erbB-2 transgenic mice

    Although chemopreventative agents targeting the estrogen/estrogen receptor (ER) pathway have been effective for ER+ breast cancers, prevention of hormone receptor-negative breast cancers, such as Her2/erbB-2+ bre...

    Zhikun Ma, Amanda B. Parris, Zhengzheng Xiao, Erin W. Howard, Stanley D. Kosanke, Xiaoshan Feng and Xiaohe Yang

    Journal of Experimental & Clinical Cancer Research 2017 36:6

    Published on: 6 January 2017

  15. Research

    Downregulation of long noncoding RNA MEG3 is associated with poor prognosis and promoter hypermethylation in cervical cancer

    Our previous study reported that MEG3 is an important tumor suppressor gene that is inactivated in cervical cancer. However, the diagnostic and prognostic values of MEG3, as well as the molecular mechanism of MEG...

    Jun Zhang, Zhongqiu Lin, Yali Gao and Tingting Yao

    Journal of Experimental & Clinical Cancer Research 2017 36:5

    Published on: 5 January 2017

  16. Research

    RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer

    Retinoic acid-inducible gene-I (Rig-I) is an intracellular viral RNA receptor, which specifically recognizes double-stranded viral RNA initiating antiviral innate immunity. Increasing evidences showed that Rig...

    Houbao Zhu, Wang-Yang Xu, Zhiqiang Hu, Hongxin Zhang, Yan Shen, Shunyuan Lu, Chaochun Wei and Zhu-Gang Wang

    Journal of Experimental & Clinical Cancer Research 2017 36:2

    Published on: 5 January 2017

  17. Research

    Nomogram integrating gene expression signatures with clinicopathological features to predict survival in operable NSCLC: a pooled analysis of 2164 patients

    The current tumor-node-metastasis (TNM) staging system is insufficient to predict outcome of patients with operable Non-Small Cell Lung Cancer (NSCLC) owing to its phenotypic and genomic heterogeneity. Integra...

    Jian Wu, Lizhi Zhou, Lixia Huang, Jincui Gu, Shaoli Li, Baomo Liu, Jinlun Feng and Yanbin Zhou

    Journal of Experimental & Clinical Cancer Research 2017 36:4

    Published on: 5 January 2017

  18. Research

    Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine

    More effective chemotherapies are urgently needed for bladder cancer, a major cause of morbidity and mortality worldwide. We therefore explored the efficacy of the combination of gemcitabine and AZD7762, a che...

    Makoto Isono, Michèle J. Hoffmann, Maria Pinkerneil, Akinori Sato, Martin Michaelis, Jindrich Cinatl, Günter Niegisch and Wolfgang A. Schulz

    Journal of Experimental & Clinical Cancer Research 2017 36:1

    Published on: 3 January 2017

  19. Research

    A piperazidine derivative of 23-hydroxy betulinic acid induces a mitochondria-derived ROS burst to trigger apoptotic cell death in hepatocellular carcinoma cells

    Elevated production of reactive oxygen species (ROS) and an altered redox state have frequently been observed in hepatocellular carcinoma (HCC); therefore, selective killing of HCC cells by chemotherapeutic ag...

    Nan Yao, Ying-jie Li, Yu-he Lei, Nan Hu, Wei-Min Chen, Zhe Yao, Miao Yu, Jun-shan Liu, Wen-cai Ye and Dong-mei Zhang

    Journal of Experimental & Clinical Cancer Research 2016 35:192

    Published on: 8 December 2016

  20. Research

    Elaboration of a nomogram to predict nonsentinel node status in breast cancer patients with positive sentinel node, intraoperatively assessed with one step nucleic amplification: Retrospective and validation phase

    Tumor-positive sentinel lymph node (SLN) biopsy results in a risk of non sentinel node metastases in micro- and macro-metastases ranging from 20 to 50%, respectively. Therefore, most patients underwent unneces...

    Franco Di Filippo, Simona Di Filippo, Anna Maria Ferrari, Raffaele Antonetti, Alessandro Battaglia, Francesca Becherini, Laia Bernet, Renzo Boldorini, Catherine Bouteille, Simonetta Buglioni, Paolo Burelli, Rafael Cano, Vincenzo Canzonieri, Pierluigi Chiodera, Alfredo Cirilli, Luigi Coppola…

    Journal of Experimental & Clinical Cancer Research 2016 35:193

    Published on: 8 December 2016

  21. Review

    Sirtuins in metabolism, DNA repair and cancer

    The mammalian sirtuin family has attracted tremendous attention over the past few years as stress adaptors and post-translational modifier. They have involved in diverse cellular processes including DNA repair...

    Zhen Mei, Xian Zhang, Jiarong Yi, Junjie Huang, Jian He and Yongguang Tao

    Journal of Experimental & Clinical Cancer Research 2016 35:182

    Published on: 5 December 2016

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