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  1. Erratum

    Erratum to: CDC42-interacting protein 4 promotes metastasis of nasopharyngeal carcinoma by mediating invadopodia formation and activating EGFR signaling

    Dong-Fang Meng, Ping Xie, Li-Xia Peng, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Xing Lv, Lin Wang, Ming-Yuan Chen, Hai-Qiang Mai, Ling Guo, Xiang Guo, Li-Sheng Zheng, Li Cao, Jun-Ping Yang, Meng-Yao Wang…

    Journal of Experimental & Clinical Cancer Research 2017 36:33

    Published on: 20 February 2017

    The original article was published in Journal of Experimental & Clinical Cancer Research 2017 36:21

  2. Research

    Che-1 sustains hypoxic response of colorectal cancer cells by affecting Hif-1α stabilization

    Solid tumours are less oxygenated than normal tissues. Consequently, cancer cells acquire to be adapted to a hypoxic environment. The poor oxygenation of solid tumours is also a major indicator of an adverse c...

    Tiziana Bruno, Mariacristina Valerio, Luca Casadei, Francesca De Nicola, Frauke Goeman, Matteo Pallocca, Valeria Catena, Simona Iezzi, Cristina Sorino, Agata Desantis, Cesare Manetti, Giovanni Blandino, Aristide Floridi and Maurizio Fanciulli

    Journal of Experimental & Clinical Cancer Research 2017 36:32

    Published on: 18 February 2017

  3. Erratum

    Erratum to: Pathologically decreased expression of miR-193a contributes to metastasis by targeting WT1-E-cadherin axis in non-small cell lung cancers

    Junjie Chen, Shenmeng Gao, Chunjing Wang, Zhonggai Wang, Huxiang Zhang, Kate Huang, Bin Zhou, Haiying Li, Zhijie Yu, Jianbo Wu and Chengshui Chen

    Journal of Experimental & Clinical Cancer Research 2017 36:31

    Published on: 16 February 2017

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:173

  4. Research

    PEG10 overexpression induced by E2F-1 promotes cell proliferation, migration, and invasion in pancreatic cancer

    Overexpression of paternally expressed gene-10 (PEG10) is known to promote the progression of several carcinomas, however, its role in pancreatic cancer (PC) is unknown. We investigated the expression and func...

    Yun-Peng Peng, Yi Zhu, Ling-Di Yin, Jing-Jing Zhang, Ji-Shu Wei, Xian Liu, Xin-Chun Liu, Wen-Tao Gao, Kui-Rong Jiang and Yi Miao

    Journal of Experimental & Clinical Cancer Research 2017 36:30

    Published on: 13 February 2017

  5. Research

    MicroRNA-381 inhibits the metastasis of gastric cancer by targeting TMEM16A expression

    MicroRNA-381 (miR-381) has been reported to play suppressive or promoting roles in different malignancies. However, the expression level, biological function, and underlying mechanisms of miR-381 in gastric ca...

    Qinghua Cao, Fang Liu, Kaiyuan Ji, Ni Liu, Yuan He, Wenhui Zhang and Liantang Wang

    Journal of Experimental & Clinical Cancer Research 2017 36:29

    Published on: 13 February 2017

  6. Research

    Buformin inhibits the stemness of erbB-2-overexpressing breast cancer cells and premalignant mammary tissues of MMTV-erbB-2 transgenic mice

    Metformin, an FDA-approved drug for the treatment of Type II diabetes, has emerged as a promising anti-cancer agent. Other biguanide analogs, including buformin and phenformin, are suggested to have similar pr...

    Amanda B. Parris, Qingxia Zhao, Erin W. Howard, Ming Zhao, Zhikun Ma and Xiaohe Yang

    Journal of Experimental & Clinical Cancer Research 2017 36:28

    Published on: 13 February 2017

  7. Research

    Human breast adipose tissue: characterization of factors that change during tumor progression in human breast cancer

    Adipose microenvironment is involved in signaling pathways that influence breast cancer. We aim to characterize factors that are modified: 1) in tumor and non tumor human breast epithelial cell lines when incu...

    Sabrina Johanna Fletcher, Paula Alejandra Sacca, Mercedes Pistone-Creydt, Federico Andrés Coló, María Florencia Serra, Flavia Eliana Santino, Corina Verónica Sasso, Constanza Matilde Lopez-Fontana, Rubén Walter Carón, Juan Carlos Calvo and Virginia Pistone-Creydt

    Journal of Experimental & Clinical Cancer Research 2017 36:26

    Published on: 7 February 2017

  8. Research

    Cancer cells increase endothelial cell tube formation and survival by activating the PI3K/Akt signalling pathway

    Angiogenesis is a hallmark of cancer and plays a critical role in lung cancer progression, which involves interactions between cancer cells, endothelial cells and the surrounding microenvironment. However, the...

    Hao-Wei Cheng, Yi-Fang Chen, Jau-Min Wong, Chia-Wei Weng, Hsuan-Yu Chen, Sung-Liang Yu, Huei-Wen Chen, Ang Yuan and Jeremy J.W. Chen

    Journal of Experimental & Clinical Cancer Research 2017 36:27

    Published on: 7 February 2017

  9. Research

    Regulation of submaxillary gland androgen-regulated protein 3A via estrogen receptor 2 in radioresistant head and neck squamous cell carcinoma cells

    Molecular mechanisms of intrinsic or acquired radioresistance serve as critical barrier for curative therapy of head and neck squamous cell carcinoma (HNSCC) and remain a major obstacle for progression-free an...

    Jennifer Grünow, Chao Rong, Jan Hischmann, Karim Zaoui, Christa Flechtenmacher, Klaus-Josef Weber, Peter Plinkert and Jochen Hess

    Journal of Experimental & Clinical Cancer Research 2017 36:25

    Published on: 6 February 2017

  10. Research

    Intracellular pH-responsive and rituximab-conjugated mesoporous silica nanoparticles for targeted drug delivery to lymphoma B cells

    One of the main problems in B cell lymphoma treatment is severe adverse effects and low therapeutic efficacy resulting from systemic chemotherapy. A pH-sensitive controlled drug release system based on mesopor...

    Shoubing Zhou, Dan Wu, Xiaodong Yin, Xiaoxiao Jin, Xiu Zhang, Shiya Zheng, Cailian Wang and Yanwen Liu

    Journal of Experimental & Clinical Cancer Research 2017 36:24

    Published on: 6 February 2017

  11. Research

    Aberrant activation of hedgehog signaling promotes cell proliferation via the transcriptional activation of forkhead Box M1 in colorectal cancer cells

    Recent evidence suggests that the aberrant activation of Hedgehog (Hh) signaling by Gli transcription factors is characteristic of a variety of aggressive human carcinomas, including colorectal cancer (CRC). F...

    DeJie Wang, Guohui Hu, Ying Du, Cheng Zhang, Quqin Lu, Nonghua Lv and Shiwen Luo

    Journal of Experimental & Clinical Cancer Research 2017 36:23

    Published on: 2 February 2017

  12. Research

    Disulfiram overcomes bortezomib and cytarabine resistance in Down-syndrome-associated acute myeloid leukemia cells

    Children with Down syndrome (DS) have increased risk for developing AML (DS-AMKL), and they usually experience severe therapy-related toxicities compared to non DS-AMKL. Refractory/relapsed disease has very po...

    Ranjan Bista, David W. Lee, Oliver B. Pepper, David O. Azorsa, Robert J. Arceci and Eiman Aleem

    Journal of Experimental & Clinical Cancer Research 2017 36:22

    Published on: 1 February 2017

  13. Research

    CDC42-interacting protein 4 promotes metastasis of nasopharyngeal carcinoma by mediating invadopodia formation and activating EGFR signaling

    Nasopharyngeal carcinoma (NPC) is a common malignancy in Southern China and Southeast Asia. In this study, we investigated the functional and molecular mechanisms by which CDC42-interacting protein 4 (CIP4) in...

    Dong-Fang Meng, Ping Xie, Li-Xia Peng, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Xing Lv, Lin Wang, Ming-Yuan Chen, Hai-Qiang Mai, Ling Guo, Xiang Guo, Li-Sheng Zheng, Li Cao, Jun-Ping Yang, Meng-Yao Wang…

    Journal of Experimental & Clinical Cancer Research 2017 36:21

    Published on: 28 January 2017

    The Erratum to this article has been published in Journal of Experimental & Clinical Cancer Research 2017 36:33

  14. Research

    HERV-K activation is strictly required to sustain CD133+ melanoma cells with stemness features

    Melanoma is a heterogeneous tumor in which phenotype-switching and CD133 marker have been associated with metastasis promotion and chemotherapy resistance. CD133 positive (CD133+) subpopulation has also been s...

    Ayele Argaw-Denboba, Emanuela Balestrieri, Annalucia Serafino, Chiara Cipriani, Ilaria Bucci, Roberta Sorrentino, Ilaria Sciamanna, Alessandra Gambacurta, Paola Sinibaldi-Vallebona and Claudia Matteucci

    Journal of Experimental & Clinical Cancer Research 2017 36:20

    Published on: 26 January 2017

  15. Research

    Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN/Akt signaling pathway in gastric cancer

    Gastric cancer is one of the major causes of cancer-related mortality worldwide. Most of patients presenting with inoperable gastric cancers rely on systemic chemotherapy for prolongation of survival. Doxorubi...

    Jiahui Xu, Deying Liu, Huilin Niu, Guifang Zhu, Yangwei Xu, Danli Ye, Jian Li and Qingling Zhang

    Journal of Experimental & Clinical Cancer Research 2017 36:19

    Published on: 26 January 2017

  16. Research

    MIF/CD74 axis is a target for novel therapies in colon carcinomatosis

    Strategies aimed at obtaining a complete cytoreduction are needed to improve long-term survival for patients with colorectal cancer peritoneal carcinomatosis (CRC-pc).

    Fabio Bozzi, Angela Mogavero, Luca Varinelli, Antonino Belfiore, Giacomo Manenti, Claudio Caccia, Chiara C. Volpi, Galina V. Beznoussenko, Massimo Milione, Valerio Leoni, Annunziata Gloghini, Alexandre A. Mironov, Ermanno Leo, Silvana Pilotti, Marco A. Pierotti, Italia Bongarzone…

    Journal of Experimental & Clinical Cancer Research 2017 36:16

    Published on: 23 January 2017

  17. Research

    Regulation of TRIM24 by miR-511 modulates cell proliferation in gastric cancer

    Increasing evidence highlights the important roles of tripartite motif containing 24 (TRIM24) in tumor initiation and malignant progression in many tumors, including gastric cancer (GC). Although TRIM24 expres...

    Ziling Fang, Ling Zhang, Quan Liao, Yi Wang, Feng Yu, Miao Feng, Xiaojun Xiang and Jianping Xiong

    Journal of Experimental & Clinical Cancer Research 2017 36:17

    Published on: 23 January 2017

  18. Research

    Pro-inflammation NF-κB signaling triggers a positive feedback via enhancing cholesterol accumulation in liver cancer cells

    Hepatocellular carcinoma (HCC) develops in a complex microenvironment characterized by chronic inflammation. In recent years, cholesterol metabolic abnormalities have been implicated the importance in cancer c...

    Mingyan He, Wenhui Zhang, Yinying Dong, Lishun Wang, Tingting Fang, Wenqing Tang, Bei Lv, Guanglang Chen, Biwei Yang, Peixin Huang and Jinglin Xia

    Journal of Experimental & Clinical Cancer Research 2017 36:15

    Published on: 18 January 2017

  19. Research

    The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer

    Pancreatic cancer is a lethal malignancy that frequently acquires resistance to conventional chemotherapies often associated with overexpression of inhibitors of apoptosis proteins (IAPs). We have recently des...

    Yassar M. Hashim, Suwanna Vangveravong, Narendra V. Sankpal, Pratibha S. Binder, Jingxia Liu, S. Peter Goedegebuure, Robert H. Mach, Dirk Spitzer and William G. Hawkins

    Journal of Experimental & Clinical Cancer Research 2017 36:14

    Published on: 17 January 2017

  20. Review

    Deptor: not only a mTOR inhibitor

    Deptor is an important protein that belongs to the mTORC1 and mTORC2 complexes, able to interact with mTOR and to inhibit its kinase activity. As a natural mTOR inhibitor, Deptor is involved in several molecul...

    Valeria Catena and Maurizio Fanciulli

    Journal of Experimental & Clinical Cancer Research 2017 36:12

    Published on: 13 January 2017

  21. Research

    Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes tumorigenesis and metastasis by targeting miR-199a/b-5p in hepatocellular carcinoma

    Hepatocellular carcinoma (HCC) is third leading cause of cancer-related death globally. Evidence suggest that long non-coding RNAs (lncRNAs) have emerged as key regulators of tumorigenesis and metastasis in HC...

    Tian Lan, Weijie Ma, Zhenfei Hong, Long Wu, Xi Chen and Yufeng Yuan

    Journal of Experimental & Clinical Cancer Research 2017 36:11

    Published on: 10 January 2017

  22. Research

    Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation

    The ubiquitin-ligase Fbw7 acts as a tumor suppressor, targeting lots of proto-oncogenes for proteolysis. However, the exact role of Fbw7 in diffuse large B-cell lymphoma (DLBCL) development remains unclear.

    Su Yao, Fangping Xu, Yu Chen, Yan Ge, Fen Zhang, Huijie Huang, Li Li, Danyi Lin, Xinlan Luo, Jie Xu, Donglan Luo, Xiaolan Zhu and Yanhui Liu

    Journal of Experimental & Clinical Cancer Research 2017 36:10

    Published on: 10 January 2017

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