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  1. Research

    FGF19/FGFR4 signaling contributes to the resistance of hepatocellular carcinoma to sorafenib

    Sorafenib, a multi-kinase inhibitor, is used as a standard therapy for advanced hepatocellular carcinoma (HCC). However, complete remission has not been achieved and the molecular basis of HCC resistance to so...

    Lixia Gao, Xuli Wang, Yaoliang Tang, Shuang Huang, Chien-An Andy Hu and Yong Teng

    Journal of Experimental & Clinical Cancer Research 2017 36:8

    Published on: 9 January 2017

  2. Research

    Motility of glioblastoma cells is driven by netrin-1 induced gain of stemness

    Glioblastoma is an untreatable brain cancer. The tumors contain a population of stem-like cells which are highly invasive and resistant to therapies. These cells are the main reason for the lethality of gliobl...

    Irene Ylivinkka, Harri Sihto, Olli Tynninen, Yizhou Hu, Aki Laakso, Riku Kivisaari, Pirjo Laakkonen, Jorma Keski-Oja and Marko Hyytiäinen

    Journal of Experimental & Clinical Cancer Research 2017 36:9

    Published on: 9 January 2017

  3. Research

    Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma

    Many cancers including head and neck squamous cell carcinoma (HNSCC) are characterized by a metabolic rewiring with increased glucose uptake and lactate production, termed as aerobic glycolysis. Targeting aero...

    Hui-Min Li, Jie-Gang Yang, Zhuo-Jue Liu, Wei-Ming Wang, Zi-Li Yu, Jian-Gang Ren, Gang Chen, Wei Zhang and Jun Jia

    Journal of Experimental & Clinical Cancer Research 2017 36:7

    Published on: 7 January 2017

  4. Research

    Short-term early exposure to lapatinib confers lifelong protection from mammary tumor development in MMTV-erbB-2 transgenic mice

    Although chemopreventative agents targeting the estrogen/estrogen receptor (ER) pathway have been effective for ER+ breast cancers, prevention of hormone receptor-negative breast cancers, such as Her2/erbB-2+ bre...

    Zhikun Ma, Amanda B. Parris, Zhengzheng Xiao, Erin W. Howard, Stanley D. Kosanke, Xiaoshan Feng and Xiaohe Yang

    Journal of Experimental & Clinical Cancer Research 2017 36:6

    Published on: 6 January 2017

  5. Research

    Downregulation of long noncoding RNA MEG3 is associated with poor prognosis and promoter hypermethylation in cervical cancer

    Our previous study reported that MEG3 is an important tumor suppressor gene that is inactivated in cervical cancer. However, the diagnostic and prognostic values of MEG3, as well as the molecular mechanism of MEG...

    Jun Zhang, Zhongqiu Lin, Yali Gao and Tingting Yao

    Journal of Experimental & Clinical Cancer Research 2017 36:5

    Published on: 5 January 2017

  6. Research

    RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer

    Retinoic acid-inducible gene-I (Rig-I) is an intracellular viral RNA receptor, which specifically recognizes double-stranded viral RNA initiating antiviral innate immunity. Increasing evidences showed that Rig...

    Houbao Zhu, Wang-Yang Xu, Zhiqiang Hu, Hongxin Zhang, Yan Shen, Shunyuan Lu, Chaochun Wei and Zhu-Gang Wang

    Journal of Experimental & Clinical Cancer Research 2017 36:2

    Published on: 5 January 2017

  7. Research

    Nomogram integrating gene expression signatures with clinicopathological features to predict survival in operable NSCLC: a pooled analysis of 2164 patients

    The current tumor-node-metastasis (TNM) staging system is insufficient to predict outcome of patients with operable Non-Small Cell Lung Cancer (NSCLC) owing to its phenotypic and genomic heterogeneity. Integra...

    Jian Wu, Lizhi Zhou, Lixia Huang, Jincui Gu, Shaoli Li, Baomo Liu, Jinlun Feng and Yanbin Zhou

    Journal of Experimental & Clinical Cancer Research 2017 36:4

    Published on: 5 January 2017

  8. Research

    Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine

    More effective chemotherapies are urgently needed for bladder cancer, a major cause of morbidity and mortality worldwide. We therefore explored the efficacy of the combination of gemcitabine and AZD7762, a che...

    Makoto Isono, Michèle J. Hoffmann, Maria Pinkerneil, Akinori Sato, Martin Michaelis, Jindrich Cinatl, Günter Niegisch and Wolfgang A. Schulz

    Journal of Experimental & Clinical Cancer Research 2017 36:1

    Published on: 3 January 2017

  9. Research

    A piperazidine derivative of 23-hydroxy betulinic acid induces a mitochondria-derived ROS burst to trigger apoptotic cell death in hepatocellular carcinoma cells

    Elevated production of reactive oxygen species (ROS) and an altered redox state have frequently been observed in hepatocellular carcinoma (HCC); therefore, selective killing of HCC cells by chemotherapeutic ag...

    Nan Yao, Ying-jie Li, Yu-he Lei, Nan Hu, Wei-Min Chen, Zhe Yao, Miao Yu, Jun-shan Liu, Wen-cai Ye and Dong-mei Zhang

    Journal of Experimental & Clinical Cancer Research 2016 35:192

    Published on: 8 December 2016

  10. Research

    Elaboration of a nomogram to predict nonsentinel node status in breast cancer patients with positive sentinel node, intraoperatively assessed with one step nucleic amplification: Retrospective and validation phase

    Tumor-positive sentinel lymph node (SLN) biopsy results in a risk of non sentinel node metastases in micro- and macro-metastases ranging from 20 to 50%, respectively. Therefore, most patients underwent unneces...

    Franco Di Filippo, Simona Di Filippo, Anna Maria Ferrari, Raffaele Antonetti, Alessandro Battaglia, Francesca Becherini, Laia Bernet, Renzo Boldorini, Catherine Bouteille, Simonetta Buglioni, Paolo Burelli, Rafael Cano, Vincenzo Canzonieri, Pierluigi Chiodera, Alfredo Cirilli, Luigi Coppola…

    Journal of Experimental & Clinical Cancer Research 2016 35:193

    Published on: 8 December 2016

  11. Review

    Sirtuins in metabolism, DNA repair and cancer

    The mammalian sirtuin family has attracted tremendous attention over the past few years as stress adaptors and post-translational modifier. They have involved in diverse cellular processes including DNA repair...

    Zhen Mei, Xian Zhang, Jiarong Yi, Junjie Huang, Jian He and Yongguang Tao

    Journal of Experimental & Clinical Cancer Research 2016 35:182

    Published on: 5 December 2016

  12. Review

    Patient-derived xenografts: a relevant preclinical model for drug development

    Identifying appropriate preclinical cancer models remains a major challenge in increasing the efficiency of drug development. A potential strategy to improve patient outcomes could be selecting the ‘right’ tre...

    Luca Pompili, Manuela Porru, Carla Caruso, Annamaria Biroccio and Carlo Leonetti

    Journal of Experimental & Clinical Cancer Research 2016 35:189

    Published on: 5 December 2016

  13. Research

    MicroRNA-19b-3p regulates nasopharyngeal carcinoma radiosensitivity by targeting TNFAIP3/NF-κB axis

    Nasopharyngeal carcinoma (NPC) is among the most common squamous cell carcinoma in South China and Southeast Asia. Radiotherapy is the primary treatment for NPC. However, radioresistance acts as a significant ...

    Teng Huang, Li Yin, Jing Wu, Jia-Jia Gu, Jian-Zhong Wu, Dan Chen, Hong-Liang Yu, Kai Ding, Nan Zhang, Ming-Yu Du, Lu-Xi Qian, Zhi-Wei Lu and Xia He

    Journal of Experimental & Clinical Cancer Research 2016 35:188

    Published on: 5 December 2016

  14. Research

    CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells

    Coiled-Coil Domain Containing 88A (CCDC88A) was identified as a substrate of the serine/threonine kinase Akt that is capable of binding to the actin cytoskeleton. The aim of this study was to investigate the p...

    Aki Tanouchi, Keisuke Taniuchi, Mutsuo Furihata, Seiji Naganuma, Ken Dabanaka, Masashi Kimura, Ryohei Watanabe, Takuhiro Kohsaki, Takahiro Shimizu, Motoaki Saito, Kazuhiro Hanazaki and Toshiji Saibara

    Journal of Experimental & Clinical Cancer Research 2016 35:190

    Published on: 5 December 2016

  15. Research

    A novel long non-coding RNA lnc-GNAT1-1 is low expressed in colorectal cancer and acts as a tumor suppressor through regulating RKIP-NF-κB-Snail circuit

    The role of long non-coding RNAs (lncRNAs) in colorectal cancer (CRC) progression has not fully been elucidated. This study was designed to report the identification of a novel lncRNA, lnc-GNAT1-1, and its fun...

    Chunxiang Ye, Zhanlong Shen, Bo Wang, Yansen Li, Tao Li, Yang Yang, Kewei Jiang, Yingjiang Ye and Shan Wang

    Journal of Experimental & Clinical Cancer Research 2016 35:187

    Published on: 3 December 2016

  16. Research

    Exosomes play an important role in the process of psoralen reverse multidrug resistance of breast cancer

    Release of exosomes have been shown to play critical roles in drug resistance by delivering cargo. Targeting the transfer of exosomes from resistant cells to sensitive cells may be an approach to overcome some...

    Xiaohong Wang, Chengfeng Xu, Yitong Hua, Leitao Sun, Kai Cheng, Zhongming Jia, Yong Han, Jianli Dong, Yuzhen Cui and Zhenlin Yang

    Journal of Experimental & Clinical Cancer Research 2016 35:186

    Published on: 1 December 2016

  17. Erratum

    Erratum to: Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer

    Andrea Prodosmo, Amelia Buffone, Manlio Mattioni, Agnese Barnabei, Agnese Persichetti, Aurora De Leo, Marialuisa Appetecchia, Arianna Nicolussi, Anna Coppa, Salvatore Sciacchitano, Carolina Giordano, Paola Pinnarò, Giuseppe Sanguineti, Lidia Strigari, Gabriele Alessandrini, Francesco Facciolo…

    Journal of Experimental & Clinical Cancer Research 2016 35:185

    Published on: 28 November 2016

    The original article was published in Journal of Experimental & Clinical Cancer Research 2016 35:135

  18. Research

    GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment

    The aim of this study was to investigate the effect of downregulating Hedgehog pathway by GANT61 on human glioma cells, examine the consequent changes of temozolomide (TMZ)-induced effects and explore the mole...

    Jianlong Li, Jinquan Cai, Shihong Zhao, Kun Yao, Ying Sun, Yongli Li, Lingchao Chen, Ruiyan Li, Xiuwei Zhai, Junhe Zhang and Chuanlu Jiang

    Journal of Experimental & Clinical Cancer Research 2016 35:184

    Published on: 28 November 2016

  19. Research

    HPV16 integration probably contributes to cervical oncogenesis through interrupting tumor suppressor genes and inducing chromosome instability

    The integration of human papilloma virus (HPV) into host genome is one of the critical steps that lead to the progression of precancerous lesion into cancer. However, the mechanisms and consequences of such in...

    Jun-Wei Zhao, Fang Fang, Yi Guo, Tai-Lin Zhu, Yun-Yun Yu, Fan-Fei Kong, Ling-Fei Han, Dong-Sheng Chen and Fang Li

    Journal of Experimental & Clinical Cancer Research 2016 35:180

    Published on: 25 November 2016

  20. Research

    Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases

    Overexpression of Aurora A and B has been reported in a wide range of tumor types, including gastric cancer. Anti-angiogenesis has been considered as an important therapeutic modality in advanced gastric cance...

    Wang Liu, Yu Lu, Xiaoping Chai, Xiao Liu, Tong Zhu, Xihan Wu, Yanfen Fang, Xuan Liu and Xiongwen Zhang

    Journal of Experimental & Clinical Cancer Research 2016 35:183

    Published on: 25 November 2016

  21. Research

    Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion

    Hyaluronan synthases (HAS) control the biosynthesis of hyaluronan (HA) and critically modulate the tumor microenviroment. Cancer-associated fibroblasts (CAFs) affect the progression of a tumor by remolding the...

    Ziwen Zhang, Detao Tao, Ping Zhang, Xue Liu, Yuchao Zhang, Jie Cheng, Hua Yuan, Laikui Liu and Hongbing Jiang

    Journal of Experimental & Clinical Cancer Research 2016 35:181

    Published on: 25 November 2016

  22. Review

    Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic

    DNA damage response (DDR) defects imply genomic instability and favor tumor progression but make the cells vulnerable to the pharmacological inhibition of the DNA repairing enzymes. Targeting cellular proteins...

    Aniello Cerrato, Francesco Morra and Angela Celetti

    Journal of Experimental & Clinical Cancer Research 2016 35:179

    Published on: 24 November 2016

  23. Research

    Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II

    Lapachol is a natural naphthoquinone compound that possesses extensive biological activities. The aim of this study is to investigate the inhibitory effects of lapachol on rat C6 glioma both in vitro and in vi...

    Huanli Xu, Qunying Chen, Hong Wang, Pingxiang Xu, Ru Yuan, Xiaorong Li, Lu Bai and Ming Xue

    Journal of Experimental & Clinical Cancer Research 2016 35:178

    Published on: 16 November 2016

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