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  1. Research

    Overexpression of miR-584-5p inhibits proliferation and induces apoptosis by targeting WW domain-containing E3 ubiquitin protein ligase 1 in gastric cancer

    MicroRNAs are endogenously expressed, small non-coding RNAs that modulate gene expression by targeting specific mRNAs, resulting in translational repression or mRNA degradation. Although miR-584-5p has been re...

    Qing Li, Zheng Li, Song Wei, Weizhi Wang, Zheng Chen, Lei Zhang, Liang Chen, Bowen Li, Guangli Sun, Jianghao Xu, Qiang Li, Lu Wang, Zhipeng Xu, Yiwen Xia, Diancai Zhang, Hao Xu…

    Journal of Experimental & Clinical Cancer Research 2017 36:59

    Published on: 21 April 2017

  2. Research

    Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2

    Hexokinase (HK) is the rate-limiting enzyme in the first reaction of glycolysis. And Hexokinase 2 (HK2) is most closely related to malignant tumor which expresses at higher level compared with normal cells. HK...

    Wei Li, Mengzhu Zheng, Shuangping Wu, Suyu Gao, Mei Yang, Zhimei Li, Qiuxia Min, Weiguang Sun, Lixia Chen, Guangya Xiang and Hua Li

    Journal of Experimental & Clinical Cancer Research 2017 36:58

    Published on: 20 April 2017

  3. Research

    Vitamin D receptor, Retinoid X receptor and peroxisome proliferator-activated receptor γ are overexpressed in BRCA1 mutated breast cancer and predict prognosis

    BRCA1 mutated breast cancers are commonly diagnosed as negative for classical hormone receptors i.e. estrogen receptor, progesterone receptor and/or Her2. Due to these common targets b...

    Sabine Heublein, Doris Mayr, Alfons Meindl, Alexandra Kircher, Udo Jeschke and Nina Ditsch

    Journal of Experimental & Clinical Cancer Research 2017 36:57

    Published on: 20 April 2017

  4. Research

    Genotypes of SLC22A4 and SLC22A5 regulatory loci are predictive of the response of chronic myeloid leukemia patients to imatinib treatment

    Through high-throughput next-generation sequencing of promoters of solute carrier and ATP-binding cassette genes, which encode drug transporters, we aimed to identify SNPs associated with the response to imati...

    Monika Jaruskova, Nikola Curik, Rajna Hercog, Vaclava Polivkova, Eliska Motlova, Vladimir Benes, Hana Klamova, Pavla Pecherkova, Petra Belohlavkova, Filip Vrbacky and Katerina Machova Polakova

    Journal of Experimental & Clinical Cancer Research 2017 36:55

    Published on: 18 April 2017

  5. Research

    Elevated Gab2 induces tumor growth and angiogenesis in colorectal cancer through upregulating VEGF levels

    Grb2-associated binder 2 (Gab2) is a scaffolding protein that serves as a critical signaling amplifier downstream of tyrosine kinase receptors. Our previous study has shown that Gab2 induces epithelial-to-mese...

    Chenbo Ding, Junmin Luo, Xiaobo Fan, Longmei Li, Shanshan Li, Kunming Wen, Jihong Feng and Guoqiu Wu

    Journal of Experimental & Clinical Cancer Research 2017 36:56

    Published on: 18 April 2017

  6. Research

    Long non-coding RNA NKILA inhibits migration and invasion of non-small cell lung cancer via NF-κB/Snail pathway

    Numerous studies have shown that long non-coding RNAs (lncRNAs) play key roles during multiple cancer processes, such as cell proliferation, apoptosis, migration and invasion. The previous studies found that N...

    Zhiliang Lu, Yuan Li, Jingnan Wang, Yun Che, Shouguo Sun, Jianbing Huang, Zhaoli Chen and Jie He

    Journal of Experimental & Clinical Cancer Research 2017 36:54

    Published on: 17 April 2017

  7. Research

    Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells

    Cisplatin-based chemotherapy is frequently used to treat advanced gastric cancer (GC). However, the resistance often occurs with the mechanisms being not well understood. Recently, emerging evidence indicates ...

    Peiming Zheng, Lei Chen, Xiangliang Yuan, Qin Luo, Yi Liu, Guohua Xie, Yanhui Ma and Lisong Shen

    Journal of Experimental & Clinical Cancer Research 2017 36:53

    Published on: 13 April 2017

  8. Research

    The long non-coding RNA TP73-AS1 modulates HCC cell proliferation through miR-200a-dependent HMGB1/RAGE regulation

    P73 antisense RNA 1 T (non-protein coding), also known as TP73-AS1, is a long non-coding RNA (lncRNA) which is involved in cell proliferation and the development of tumors. However, the exact effects and molec...

    Shaling Li, Yan Huang, Yun Huang, Yongming Fu, Daolin Tang, Rui Kang, Rongrong Zhou and Xue-gong Fan

    Journal of Experimental & Clinical Cancer Research 2017 36:51

    Published on: 12 April 2017

  9. Research

    Distinct activity of the bone-targeted gallium compound KP46 against osteosarcoma cells - synergism with autophagy inhibition

    Osteosarcoma is the most frequent primary malignant bone tumor. Although survival has distinctly increased due to neoadjuvant chemotherapy in the past, patients with metastatic disease and poor response to che...

    Bernd Kubista, Thomas Schoefl, Lisa Mayr, Sushilla van Schoonhoven, Petra Heffeter, Reinhard Windhager, Bernhard K. Keppler and Walter Berger

    Journal of Experimental & Clinical Cancer Research 2017 36:52

    Published on: 12 April 2017

  10. Research

    iASPP induces EMT and cisplatin resistance in human cervical cancer through miR-20a-FBXL5/BTG3 signaling

    Epithelial–mesenchymal transition (EMT) and dysregulated microRNAs (miRNAs) have important roles in driving chemoresistance. We previously reported that iASPP is a key EMT inducer and could increase cisplatin ...

    Ying Xiong, Fei Sun, Peixin Dong, Hidemichi Watari, Junming Yue, Min-fei Yu, Chun-yan Lan, Yin Wang and Ze-biao Ma

    Journal of Experimental & Clinical Cancer Research 2017 36:48

    Published on: 11 April 2017

  11. Research

    Itraconazole induces apoptosis and cell cycle arrest via inhibiting Hedgehog signaling in gastric cancer cells

    Itraconazole has been proved therapeutically effective against a variety of human cancers. This study assessed the effect of itraconazole on the Hedgehog (Hh) pathway and proliferation of human gastric cancer ...

    Qiang Hu, Yi-Chao Hou, Jiao Huang, Jing-Yuan Fang and Hua Xiong

    Journal of Experimental & Clinical Cancer Research 2017 36:50

    Published on: 11 April 2017

  12. Research

    The role of c-Myc-RBM38 loop in the growth suppression in breast cancer

    RNA-binding protein 38 (RBM38) is a member of the RNA recognition motif (RRM) family of RNA-binding proteins (RBPs). RBM38 often exerts its function by forming regulatory loops with relevant genes. c-Myc is an...

    Xiao-Xia Li, Liang Shi, Xu-Jie Zhou, Jing Wu, Tian-Song Xia, Wen-Bin Zhou, Xi Sun, Lei Zhu, Ji-Fu Wei and Qiang Ding

    Journal of Experimental & Clinical Cancer Research 2017 36:49

    Published on: 11 April 2017

  13. Research

    Curcumin suppresses gastric tumor cell growth via ROS-mediated DNA polymerase γ depletion disrupting cellular bioenergetics

    Curcumin, as a pro-apoptotic agent, is extensively studied to inhibit tumor cell growth of various tumor types. Previous work has demonstrated that curcumin inhibits cancer cell growth by targeting multiple si...

    Lihua Wang, Xiwen Chen, Zhuanyun Du, Gefei Li, Mayun Chen, Xi Chen, Guang Liang and Tongke Chen

    Journal of Experimental & Clinical Cancer Research 2017 36:47

    Published on: 31 March 2017

  14. Research

    Sex-determining region Y-box protein 3 induces epithelial-mesenchymal transition in osteosarcoma cells via transcriptional activation of Snail1

    The transcription factor sex-determining region Y-box protein 3 (SOX3) plays important roles in various types of cancer. However, its expression and function have not yet been elucidated in osteosarcoma (OS).

    Manle Qiu, Daoyun Chen, Chaoyong Shen, Ji Shen, Huakun Zhao and Yaohua He

    Journal of Experimental & Clinical Cancer Research 2017 36:46

    Published on: 23 March 2017

  15. Research

    MicroRNA-27a contributes to the malignant behavior of gastric cancer cells by directly targeting PH domain and leucine-rich repeat protein phosphatase 2

    Accumulating evidence indicates that microRNA-27a (miR-27a) is involved in carcinogenesis and tumor progression. However, the exact function and molecular mechanism of miR-27a in gastric cancer remain unclear.

    Lei Ding, Shanyong Zhang, Mu Xu, Renwen Zhang, Pengcheng Sui and Qing Yang

    Journal of Experimental & Clinical Cancer Research 2017 36:45

    Published on: 21 March 2017

  16. Research

    Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2

    Hexokinase-2(HK-2) plays dual roles in glucose metabolism and mediation of cell apoptosis, making it an attractive target for cancer therapy. Chrysin is a natural flavone found in plant extracts which are wide...

    Dong Xu, Junzhe Jin, Hao Yu, Zheming Zhao, Dongyan Ma, Chundong Zhang and Honglei Jiang

    Journal of Experimental & Clinical Cancer Research 2017 36:44

    Published on: 20 March 2017

  17. Research

    Inhibition of autophagy enhances the selective anti-cancer activity of tigecycline to overcome drug resistance in the treatment of chronic myeloid leukemia

    Drug resistance and disease progression are still the major obstacles in the treatment of chronic myeloid leukemia (CML). Increasing researches have demonstrated that autophagy becomes activated when cancer ce...

    Ziyuan Lu, Na Xu, Bolin He, Chengyun Pan, Yangqing Lan, Hongsheng Zhou and Xiaoli Liu

    Journal of Experimental & Clinical Cancer Research 2017 36:43

    Published on: 10 March 2017

  18. Research

    Hepatitis C virus NS3 protein enhances hepatocellular carcinoma cell invasion by promoting PPM1A ubiquitination and degradation

    Growing evidence suggests that hepatitis C virus (HCV) contributes to hepatocellular carcinoma (HCC) by directly modulating oncogenic signaling pathways. Protein phosphatase magnesium-dependent 1A (PPM1A) has ...

    Yali Zhou, Yan Zhao, Yaoying Gao, Wenjun Hu, Yan Qu, Ning Lou, Ying Zhu, Xiaoping Zhang and Hongmei Yang

    Journal of Experimental & Clinical Cancer Research 2017 36:42

    Published on: 10 March 2017

  19. Research

    Notch signaling plays a crucial role in cancer stem-like cells maintaining stemness and mediating chemotaxis in renal cell carcinoma

    Cancer stem cells (CSCs) are correlated with the initiation, chemoresistance and relapse of tumors. Notch pathway has been reported to function in CSCs maintenance, but whether it is involved in renal cell car...

    Wei Xiao, Zhiyong Gao, Yixing Duan, Wuxiong Yuan and Yang Ke

    Journal of Experimental & Clinical Cancer Research 2017 36:41

    Published on: 9 March 2017

  20. Research

    E2F8, a direct target of miR-144, promotes papillary thyroid cancer progression via regulating cell cycle

    Thyroid cancer is the most common malignancy of endocrine system, and papillary thyroid cancer (PTC) is the most common subtype. E2F8, a novel identified E2F family member, was reported to associate with progr...

    Jing Sun, Run Shi, Sha Zhao, Xiaona Li, Shan Lu, Hemei Bu, Xianghua Ma and Chuan Su

    Journal of Experimental & Clinical Cancer Research 2017 36:40

    Published on: 7 March 2017

  21. Research

    PIG3 promotes NSCLC cell mitotic progression and is associated with poor prognosis of NSCLC patients

    Non-small cell lung cancer (NSCLC) is the most commonly diagnosed type of lung cancer that is associated with poor prognosis. In this study we explored the potential role of p53-induced gene 3 (PIG3) in the pr...

    Ming Li, Shanhu Li, Biao Liu, Meng-Meng Gu, Shitao Zou, Bei-Bei Xiao, Lan Yu, Wei-Qun Ding, Ping-Kun Zhou, Jundong Zhou and Zeng-Fu Shang

    Journal of Experimental & Clinical Cancer Research 2017 36:39

    Published on: 4 March 2017

  22. Research

    Sulfasalazine attenuates evading anticancer response of CD133-positive hepatocellular carcinoma cells

    CD133-positive cells in hepatocellular carcinoma (HCC) exhibit cancer stem cell (CSC)-like properties as well as resistance to chemotherapeutic agents and ionizing radiation; however, their function remains un...

    Yeonhwa Song, Jaewoo Jang, Tae-Hoon Shin, Sang Mun Bae, Jin-sun Kim, Kang Mo Kim, Seung-Jae Myung, Eun Kyung Choi and Haeng Ran Seo

    Journal of Experimental & Clinical Cancer Research 2017 36:38

    Published on: 3 March 2017

  23. Research

    Predictive biomarkers for the efficacy of peptide vaccine treatment: based on the results of a phase II study on advanced pancreatic cancer

    The purpose of the present study was to explore novel biomarkers that can predict the clinical outcome of patients before treatment or during vaccination. These would be useful for the selection of appropriate...

    Yoshitaro Shindo, Shoichi Hazama, Nobuaki Suzuki, Haruo Iguchi, Kazuhiro Uesugi, Hiroaki Tanaka, Atsushi Aruga, Takashi Hatori, Hidenobu Ishizaki, Yuzo Umeda, Toshiyoshi Fujiwara, Tetsuya Ikemoto, Mitsuo Shimada, Kazuhiko Yoshimatsu, Hiroko Takenouchi, Hiroto Matsui…

    Journal of Experimental & Clinical Cancer Research 2017 36:36

    Published on: 28 February 2017

  24. Research

    Prognostic stratification improvement by integrating ID1/ID3/IGJ gene expression signature and immunophenotypic profile in adult patients with B-ALL

    Survival of adults with B-Acute Lymphoblastic Leukemia requires accurate risk stratification of patients in order to provide the appropriate therapy. Contemporary techniques, using clinical and cytogenetic var...

    Nataly Cruz-Rodriguez, Alba L. Combita, Leonardo J. Enciso, Lauren F. Raney, Paula L. Pinzon, Olga C. Lozano, Alba M. Campos, Niyireth Peñaloza, Julio Solano, Maria V. Herrera, Jovanny Zabaleta and Sandra Quijano

    Journal of Experimental & Clinical Cancer Research 2017 36:37

    Published on: 28 February 2017

  25. Research

    Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6

    Cancer cells are known to over-express TRAF6 that is critical for both AKT and TAK1 activations. The Really Interesting New Gene (RING) domain of TRAF6 is believed to be responsible for the E3 ligase activity,...

    Yonghao Qi, Ambara R. Pradipta, Miao Li, Xuan Zhao, Lulu Lu, Xuegang Fu, Jing Wei, Richard P. Hsung, Katsunori Tanaka and Lijun Zhou

    Journal of Experimental & Clinical Cancer Research 2017 36:35

    Published on: 23 February 2017

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