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Featured Article: The role of microenvironment in tumor angiogenesis

The role of microenvironment in tumor angiogenesis
New Content ItemTumor angiogenesis is necessary for the continued survival and development of tumor cells, and plays an important role in their growth, invasion, and metastasis. The tumor microenvironment—composed of tumor cells, surrounding cells, and secreted cytokines—provides a conducive environment for the growth and survival of tumors. Different components of the tumor microenvironment can regulate tumor development. In this review, we have discussed the regulatory role of the microenvironment in tumor angiogenesis. High expression of angiogenic factors and inflammatory cytokines in the tumor microenvironment, as well as hypoxia, are presumed to be the reasons for poor therapeutic efficacy of current anti-angiogenic drugs. A combination of anti-angiogenic drugs and antitumor inflammatory drugs or hypoxia inhibitors might improve the therapeutic outcome.

Click here to access all of the reviews published to date in Journal of Experimental & Clinical Cancer Research.

Aims and scope

Journal of Experimental & Clinical Cancer Research is an online peer-reviewed journal that provides a high-quality forum for all aspects of basic, clinical and translational work in oncology.

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Editor-in-Chief

Mauro Castelli, Regina Elena National Cancer Institute, Italy

If you would like to contact Journal of Experimental & Clinical Cancer Research, please send an email to: 

editorialjeccr@gmail.com

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Call for papers: Long non-coding and circular RNAs in the landscape of cancer progression and metastasis

lncRNA teaser image 2

Journal of Experimental & Clinical Cancer Research is delighted to announce a new thematic series focused on:

The role of long non-coding and circular RNAs as potential cancer biomarkers.

The 2022 Special Issue will accept Research Articles and Reviews regarding the latest highlights on this topic. Submit here.

  • Submission opens: 1st January 2022
  • Submission deadline: 31st December 2022

Click here to view this collection. Click here to access all thematic series published to date in Journal of Experimental & Clinical Cancer Research.

Call for Papers: Drugging cancer vulnerabilities toward innovative clinical trials

Drugging smallJournal of Experimental & Clinical Cancer Research is delighted to announce the new thematic series covering the actual knowledge of novel strategies on anticancer treatments.

The Special Issue will accept Research Articles and Reviews regarding the latest highlights on Drugging cancer vulnerabilities toward innovative clinical trials. Submit here.

  • Submission opens: 1st April 2021
  • Submission deadline: 31st December 2022

Click here to view this collection. Click here to access all thematic series published to date in Journal of Experimental & Clinical Cancer Research.

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Recognising Editorial Excellence

SN Editorial Excellence badgeJournal of Experimental & Clinical Cancer Research is a top rated Springer Nature journal. Prof. Mauro Castelli and the editorial team performed in the top percentile of journals based on data collected from the Journal Author Satisfaction Survey. We are recognising extraordinary editors for their commitment and passion to their journals. Read more about editorial excellence here.

Reviewer Acknowledgement and New Recruitment

The Editor-in-Chief of Journal of Experimental & Clinical Cancer Research would like to thank all of our reviewers who have contributed to the journal and is looking for new reviewers to assess manuscripts. For consideration, please send your CV with keywords and expertise to editorialjeccr@gmail.com

Archival content

Journal of Experimental & Clinical Cancer Research has been publishing since 1982.  Prior to publishing with BioMed Central from 2008, Journal of Experimental & Clinical Cancer Research was published in print.  For enquiries about previous content, please contact us on: 

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