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  1. Hepatocellular carcinoma (HCC) remains difficult to treat due to limited effective treatment options. While the proteasome inhibitor bortezomib has shown promising preclinical activity in HCC, clinical trials ...

    Authors: Jhin Jieh Lim, Lissa Hooi, Yock Young Dan, Glenn K. Bonney, Lei Zhou, Pierce K.-H. Chow, Cheng Ean Chee, Tan Boon Toh and Edward K.-H. Chow
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:249
  2. FAT atypical cadherin 1 (FAT1) is among the most frequently mutated genes in many types of cancer. Its highest mutation rate is found in head and neck squamous cell carcinoma (HNSCC), in which FAT1 is the seco...

    Authors: Zhuo Georgia Chen, Nabil F. Saba and Yong Teng
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:248
  3. Authors: Gonçalo Outeiro-Pinho, Daniela Barros-Silva, Elena Aznar, Ana-Isabel Sousa, Márcia Vieira-Coimbra, Jorge Oliveira, Céline S. Gonçalves, Bruno M. Costa, Kerstin Junker, Rui Henrique and Carmen Jerónimo
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:247

    The original article was published in Journal of Experimental & Clinical Cancer Research 2020 39:98

  4. Malignant transformation of the epidermis is an essential process in the pathogenesis of cutaneous squamous-cell carcinoma (cSCC). Although evidence has demonstrated that CD147 plays key roles in various tumor...

    Authors: Xu Zhang, Yeye Guo, Ta Xiao, Jie Li, Aiyuan Guo, Li Lei, Chong Jin, Qi Long, Juan Su, Mingzhu Yin, Hong Liu, Chao Chen, Zhe Zhou, Susi Zhu, Juan Tao, Shuo Hu…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:246
  5. Treatment with PARP inhibitors (PARPi) is primarily effective against high-grade serous ovarian cancers (HGSOC) with BRCA1/2 mutations or other deficiencies in homologous recombination (HR) repair mechanisms. How...

    Authors: Francesco Morra, Francesco Merolla, Giovanna Damia, Francesca Ricci, Silvia Varricchio, Gennaro Ilardi, Laura Arenare, Daniela Califano, Virginia Napolitano, Robert Fruscio, Rosa Marina Melillo, Luca Palazzo and Angela Celetti
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:245
  6. Nasopharyngeal carcinoma (NPC) arises from the epithelial cells located in the nasopharynx and has a distinct geographic distribution. Chronic Epstein-Barr virus (EBV) infection, as its most common causative a...

    Authors: Jianyun Jiang and Hongmei Ying
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:244
  7. Solid tumors subjected to intermittent hypoxia are characterized by resistance to chemotherapy and immune-killing by effector T-lymphocytes, particularly tumor-infiltrating Vγ9Vδ2 T-lymphocytes. The molecular ...

    Authors: Iris C. Salaroglio, Dimas Carolina Belisario, Muhlis Akman, Sofia La Vecchia, Martina Godel, Dario Pasquale Anobile, Giacomo Ortone, Sabrina Digiovanni, Simona Fontana, Costanzo Costamagna, Menachem Rubinstein, Joanna Kopecka and Chiara Riganti
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:243
  8. Uterine serous cancer (USC) is the most common non-endometrioid subtype of uterine cancer, and is also the most aggressive. Most patients will die of progressively chemotherapy-resistant disease, and the devel...

    Authors: Li Zhang, Chi-Lam Au-Yeung, Chunxian Huang, Tsz-Lun Yeung, Sammy Ferri-Borgogno, Barrett C. Lawson, Suet-Ying Kwan, Zheng Yin, Stephen T. Wong, Vienna Thomas, Karen H. Lu, Kay-Pong Yip, James S. K. Sham and Samuel C. Mok
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:242
  9. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a dismal prognosis. Although combined treatment with gemcitabine and albumin-bound paclitaxel has improved the prognosis of PDAC, both intri...

    Authors: Siyuan Zeng, Bin Lan, Xiaofan Ren, Shuman Zhang, Daniel Schreyer, Markus Eckstein, Hai Yang, Nathalie Britzen-Laurent, Andreas Dahl, Debabrata Mukhopadhyay, David Chang, Isabella Kutschick, Susanne Pfeffer, Peter Bailey, Andrew Biankin, Robert Grützmann…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:241
  10. Cancer-associated fibroblast (CAF) is an ideal target for cancer treatment. Recent studies have focused on eliminating CAFs and their effects by targeting their markers or blocking individual CAF-secreted fact...

    Authors: Haibo Qiu, Xu Zhang, Jiali Qi, Jiangwen Zhang, Yin Tong, Lei Li, Li Fu, Yan-Ru Qin, Xinyuan Guan and Liyi Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:240
  11. Vascular endothelial growth factor D (VEGFD), a member of the VEGF family, is implicated in angiogenesis and lymphangiogenesis, and is deemed to be expressed at a low level in cancers. S-nitrosylation, a NO (n...

    Authors: Qiangqiang He, Meiyu Qu, Tingyu Shen, Yana Xu, Jiahao Luo, Dan Tan, Chengyun Xu, Muhammad Qasim Barkat, Ling-Hui Zeng and Ximei Wu
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:239
  12. Epithelial ovarian cancer (EOC) is the leading cause of deaths among patients with gynecologic malignancies. In recent years, cancer stem cells (CSCs) have attracted great attention, which have been regarded a...

    Authors: Fei Sun, Yunjian Wei, Zheng Liu, Qiuling Jie, Xiaohui Yang, Ping Long, Jun Wang, Ying Xiong, Qi Li, Song Quan and Yanlin Ma
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:238
  13. Authors: Binghong Chen, Mengying Wang, Junjun Qiu, Keman Liao, Wenrui Zhang, Qi Lv, Chunhui Ma, Zhongrun Qian, Zhonggang Shi, Rong Liang, Yan Lin, Jiazhou Ye, Yongming Qiu and Yingying Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:237

    The original article was published in Journal of Experimental & Clinical Cancer Research 2022 41:209

  14. Radiation therapy (RT) with androgen deprivation therapy (ADT) is an effective therapy to suppress the locally advanced prostate cancer (PCa). However, we unexpectedly found that RT could also induce the andro...

    Authors: Dong Chen, Fu-Ju Chou, Yuhchyau Chen, Chi-Ping Huang, Hao Tian, Yaqin Wang, Yuanjie Niu, Bosen You, Shuyuan Yeh, Nianzeng Xing and Chawnshang Chang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:235
  15. Ocular adnexal B-cell lymphoma (OABL) is a rare subtype of non-Hodgkin lymphoma. The molecular characteristics of OABL remain poorly understood. We performed an integrated study to investigate the proteotransc...

    Authors: Jiahao Shi, Tianyu Zhu, Huimin Lin, Zhen Liu, Min Zhou, Ziyao Yu, Xiaowen Zhou, Xin Song, Yefei Wang, Renbing Jia, Xianqun Fan and Yixiong Zhou
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:234
  16. Little is known about the role of global DNA methylation in recurrence and chemoresistance of high grade serous ovarian cancer (HGSOC).

    Authors: Nicole Gull, Michelle R. Jones, Pei-Chen Peng, Simon G. Coetzee, Tiago C. Silva, Jasmine T. Plummer, Alberto Luiz P. Reyes, Brian D. Davis, Stephanie S. Chen, Kate Lawrenson, Jenny Lester, Christine Walsh, Bobbie J. Rimel, Andrew J. Li, Ilana Cass, Yonatan Berg…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:232
  17. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-018-0794-3.

    Authors: Guanqun Huang, Hui Jiang, Ye Lin, Wuzheng Xia, Yuanwei Luo, Yanpeng Wu, Weilong Cai, Xinke Zhou and Xianhan Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:231
  18. The extravasation capability of hepatocellular carcinoma (HCC) cells plays a vital role in distant metastasis. However, the underlying mechanism of extravasation in HCC lung metastasis remains largely unclear.

    Authors: Xin Zhang, Liangliang Ren, Junhua Wu, Rongni Feng, Yunyang Chen, Ronggang Li, Meimei Wu, Mingzhu Zheng, Xing Gui Wu, Wanjun Luo, Hongle He, Yanming Huang, Miaoling Tang and Jun Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:230
  19. Airborne fine particulate matter (PM2.5) has been associated with lung cancer development and progression in never smokers. However, the molecular mechanisms underlying PM2.5-induced lung cancer remain largely...

    Authors: Qianqian Chen, Yiling Wang, Lin Yang, Liyuan Sun, Yuxin Wen, Yongyi Huang, Kaiping Gao, Wenhan Yang, Feng Bai, Lijuan Ling, Zizi Zhou, Xiaoming Zhang, Juan Xiong and Rihong Zhai
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:229
  20. Abnormal glycosylation in a variety of cancer types is involved in tumor progression and chemoresistance. Glycosyltransferase C1GALT1, the key enzyme in conversion of Tn antigen to T antigen, is involved in bo...

    Authors: Zengqi Tan, Yazhuo Jiang, Liang Liang, Jinpeng Wu, Lin Cao, Xiaoman Zhou, Zhihui Song, Zhenyu Ye, Ziyan Zhao, Hui Feng, Zewen Dong, Shuai Lin, Zhangjian Zhou, Yili Wang, Xiang Li and Feng Guan
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:228
  21. CD8+ T cells play a central role in anti-tumor immunity. Naïve CD8+ T cells are active upon tumor antigen stimulation, and then differentiate into functional cells and migrate towards the tumor sites. Activate...

    Authors: Lu Zhang, Wen Zhang, Ziye Li, Shumeng Lin, Tiansheng Zheng, Bingjie Hao, Yaqin Hou, Yanfei Zhang, Kai Wang, Chenge Qin, Liduo Yue, Jing Jin, Ming Li and Lihong Fan
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:227
  22. Neuroblastoma (NB), a childhood tumor derived from the sympathetic nervous system, presents with heterogeneous clinical behavior. While some tumors regress spontaneously without medical intervention, others ar...

    Authors: Lourdes Sainero-Alcolado, Muhammad Mushtaq, Judit Liaño-Pons, Aida Rodriguez-Garcia, Ye Yuan, Tong Liu, María Victoria Ruiz-Pérez, Susanne Schlisio, Oscar Bedoya-Reina and Marie Arsenian-Henriksson
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:226
  23. Acute myeloid leukemia (AML) is a myeloid neoplasm makes up 7.6% of hematopoietic malignancies. Super-enhancers (SEs) represent a special group of enhancers, which have been reported in multiple cell types. In...

    Authors: Fang Fang, Jun Lu, Xu Sang, Yan-Fang Tao, Jian-Wei Wang, Zi-Mu Zhang, Yong-Ping Zhang, Xiao-Lu Li, Yi Xie, Shui-Yan Wu, Xin-Ran Chu, Gen Li, Di Wu, Yan-Ling Chen, Juan-Juan Yu, Si-qi Jia…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:225
  24. The tumor microenvironment (TME) has been demonstrated to modulate the biological behavior of tumors intensively. Multiple stress conditions are widely observed in the TME of many cancer types, such as hypoxia...

    Authors: Yue Lv, Yinghao Lv, Zhen Wang, Kefei Yuan and Yong Zeng
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:224
  25. Resistance to temozolomide (TMZ) is a major obstacle to preventing glioblastoma (GBM) recurrence after surgery. Although long noncoding RNAs (lncRNAs) play a variety of roles in GBM, the lncRNAs that regulate ...

    Authors: Zijie Gao, Jianye Xu, Yang Fan, Yanhua Qi, Shaobo Wang, Shulin Zhao, Xing Guo, Hao Xue, Lin Deng, Rongrong Zhao, Chong Sun, Ping Zhang and Gang Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:223
  26. The mechanism by which glioblastoma evades temozolomide (TMZ)-induced cytotoxicity is largely unknown. We hypothesized that mitochondria plays a role in this process.

    Authors: Chia-Hung Chien, Wen-Bin Yang, Jian-Ying Chuang, Jung-Shun Lee, Wei-An Liao, Chih-Yuan Huang, Pin-Yuan Chen, An-Chih Wu, Shun-Tai Yang, Chien-Cheng Lai, Pei-I Chi, Jui-Mei Chu, Siao Muk Cheng, Chan-Chuan Liu, Daw-Yang Hwang, Shang-Hung Chen…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:220
  27. The Hippo pathway functions as a tumor suppressor pathway in human cancers, while dysfunction of the Hippo pathway is frequently observed in malignancies. Although YAP/TAZ activity is tightly controlled by the...

    Authors: Dehai Wang, Zhongbo Li, Xin Li, Cheng Yan, Huijie Yang, Ting Zhuang, Xiao Wang, Yifeng Zang, Ziping Liu, Tianshi Wang, Rixia Jiang, Peng Su, Jian Zhu and Yinlu Ding
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:219
  28. Gastric cancer (GC) is an aggressive malignancy with a high mortality rate and poor prognosis, primarily caused by metastatic lesions. Improved understanding of GC metastasis at the molecular level yields mean...

    Authors: Xiaolin Wang, Jiahui Zhang, Guozhen Cao, Jinghan Hua, Ge Shan and Wenchu Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:218
  29. We aimed to determine the safety and efficacy of nintedanib, an oral anti-angiogenic tyrosine kinase inhibitor, in combination with pembrolizumab, an anti-PD1 immunotherapy, in patients with advanced solid tum...

    Authors: Capucine Baldini, Francois-Xavier Danlos, Andreea Varga, Matthieu Texier, Heloise Halse, Severine Mouraud, Lydie Cassard, Stéphane Champiat, Nicolas Signolle, Perrine Vuagnat, Patricia Martin-Romano, Jean-Marie Michot, Rastislav Bahleda, Anas Gazzah, Lisa Boselli, Delphine Bredel…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:217
  30. POLE and POLD1 encode the catalytic and proofreading subunits of DNA polymerase ε and polymerase δ, and play important roles in DNA replication and proofreading. POLE/POLD1 exonuclease domain mutations lead to lo...

    Authors: Xiaoting Ma, Lin Dong, Xiu Liu, Kai Ou and Lin Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:216
  31. Leptin is important in physiological and pathological functions in various cancers, however, the significance and mechanisms of leptin in nasopharyngeal carcinoma remain ambiguous.

    Authors: Sheng-Dean Luo, Hsin-Ting Tsai, Chung-Feng Hwang, Tai‐Jan Chiu, Shau‐Hsuan Li, Ya-Ling Hsu, Chang-Chun Hsiao and Chang-Han Chen
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:215
  32. One of the most malignant tumors in men is prostate cancer that is still incurable due to its heterogenous and progressive natures. Genetic and epigenetic changes play significant roles in its development. The...

    Authors: Sepideh Mirzaei, Mahshid Deldar Abad Paskeh, Elena Okina, Mohammad Hossein Gholami, Kiavash Hushmandi, Mehrdad Hashemi, Azuma Kalu, Ali Zarrabi, Noushin Nabavi, Navid Rabiee, Esmaeel Sharifi, Hassan Karimi-Maleh, Milad Ashrafizadeh, Alan Prem Kumar and Yuzhuo Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:214
  33. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-022-02426-x

    Authors: Yi Cao, Yi Tu, Jianbo Xiong, Shengxing Tan, Lianghua Luo, Ahao Wu, Xufeng Shu, Zhigang Jie and Zhengrong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:213
  34. Identifying biomarkers related to the diagnosis and treatment of gastric cancer (GC) has not made significant progress due to the heterogeneity of tumors. Genes involved in histological classification and gene...

    Authors: Bo-Kyung Kim, Da-Mi Kim, Hyunkyung Park, Seon-Kyu Kim, Mi-Aie Hwang, Jungwoon Lee, Mi-Jung Kang, Jae-Eun Byun, Joo-Young Im, Minho Kang, Kyung Chan Park, Young Il Yeom, Seon-Young Kim, Haiyoung Jung, Dae-Hyuk Kweon, Jae-Ho Cheong…
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:212
  35. Tumor cells exhibited phenotypic and molecular characteristics similar to their lineage progenitor cells. Liver developmental signaling pathways are showed to be associated with HCC development and oncogenesis...

    Authors: Lingxi Jiang, Xia Wang, Fangfang Ma, Xuelong Wang, Minmin Shi, Qian Yan, Ming Liu, Juan Chen, Chaoran Shi and Xin-yuan Guan
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:211
  36. Lymphoid neoplasms, including multiple myeloma (MM), non-Hodgkin lymphoma (NHL), and NK/T cell neoplasms, are a major cause of blood cancer morbidity and mortality. CD38 (cyclic ADP ribose hydrolase) is a tran...

    Authors: Xu Wang, Xinfang Yu, Wei Li, Praveen Neeli, Ming Liu, Ling Li, Mingzhi Zhang, Xiaosheng Fang, Ken H. Young and Yong Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:210
  37. Abnormal proliferation and migration of cells are hallmarks of cancer initiation and malignancy. Asparagine endopeptidase (AEP) has specific substrate cleavage ability and plays a pro-cancer role in a variety ...

    Authors: Binghong Chen, Mengying Wang, Junjun Qiu, Keman Liao, Wenrui Zhang, Qi Lv, Chunhui Ma, Zhongrun Qian, Zhonggang Shi, Rong Liang, Yan Lin, Jiazhou Ye, Yongming Qiu and Yingying Lin
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:209

    The Correction to this article has been published in Journal of Experimental & Clinical Cancer Research 2022 41:237

  38. There is no universally accepted treatment for patients with advanced papillary renal cell carcinoma (PRCC). The presence of activating mutations in MET, as well as gain of chromosome 7, where the MET gene is loc...

    Authors: Roma Pahwa, Janhavi Dubhashi, Anand Singh, Parthav Jailwala, Alexei Lobanov, Craig J. Thomas, Michele Ceribelli, Kelli Wilson, Christopher J. Ricketts, Cathy D. Vocke, Catherine Wells, Donald P. Bottaro, W. Marston Linehan, Len Neckers and Ramaprasad Srinivasan
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:208
  39. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-018-0846-8.

    Authors: Hui Jiang, Guanqun Huang, Nianzhang Zhao, Ting Zhang, Mengni Jiang, Yueming He, Xinke Zhou and Xianhan Jiang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:207
  40. Authors: Shuangjian Jiang, Chengqiang Mo, Shengjie Guo, Jintao Zhuang, Bin Huang and Xiaopeng Mao
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:206

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:495

  41. Authors: Xinnan Wu, Ruixiao Li, Qing Song, Chengcheng Zhang, Ru Jia, Zhifen Han, Lihong Zhou, Hua Sui, Xuan Liu, Huirong Zhu, Liu Yang, Yan Wang, Qing Ji and Qi Li
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:205

    The original article was published in Journal of Experimental & Clinical Cancer Research 2019 38:435

  42. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-019-1046-x.

    Authors: Jun Li, Rumeng Yang, Yuting Dong, Manyao Chen, Yu Wang and Guoping Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:204
  43. Breast cancer is the leading female cancer type and the cause of cancer-related mortality worldwide. Adipocytes possess important functions of energy supply, metabolic regulation, and cytokine release, and are...

    Authors: Xiaomei Zhou, Jun Zhang, Wenchang Lv, Chongru Zhao, Yu Xia, Yiping Wu and Qi Zhang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:203
  44. The Hippo signaling pathway was found coordinately modulates cell regeneration and organ size. Its dysregulation contributes to uncontrolled cell proliferation and malignant transformation. YAP/TAZ are two cri...

    Authors: Yirao Zhang, Yang Wang, Hao Ji, Jie Ding and Keming Wang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:202
  45. Breast cancer targeting diagnostic agent with effective imaging ability is important in guiding plan formulation, prediction, and curative effect evaluation of tumors in clinic. A tumor-targeting nanoprobe bas...

    Authors: Qiong Wu, Chanling Yuan, Ningzhi Liu, Jing Shu, Jiacheng Wang, Jiayi Qian, Liang Zeng, Hao Zhang, Xicheng Wang and Wenjie Mei
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:201
  46. The contribution of autophagy to cancer therapy resistance remains complex, mainly owing to the discrepancy of autophagy mechanisms in different therapy. However, the potential mechanisms of autophagy-mediated...

    Authors: Xin Lyu, Lizhong Zeng, Jie Shi, Zongjuan Ming, Wei Li, Boxuan Liu, Yang Chen, Bo Yuan, Ruiying Sun, Jingyan Yuan, Nannan Zhao, Xia Yang, Guoan Chen and Shuanying Yang
    Citation: Journal of Experimental & Clinical Cancer Research 2022 41:200

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