Study
|
Drug
|
Number of patients
|
End point
|
Result
|
Reference
|
---|
ATBC
|
β-Carotene
|
29,133
|
Lung cancer
|
Negative/harmful
|
[57]
|
|
α-Tocoferol
| | | | |
CARET
|
β-Carotene
|
18,314
|
Lung cancer
|
Negative/harmful
|
[58]
|
|
Retinol
| | | | |
EUROSCAN
|
Retinyl-palmitate
|
2,592
|
Second primary tumor
|
Negative
|
[38]
|
|
N-Acetycystein
| | | | |
Physician's Health Study
|
β-Carotene
|
22,071
|
Lung cancer
|
Negative
|
[59]
|
Pastorino et al.
|
Retinyl-palmitate
|
307
|
Second primary tumor
|
Positive
|
[35]
|
Lam et al.
|
ADT
|
112
|
Bronchial dysplasia
|
Positive
|
[40]
|
Kurie et al.
|
Fenretinide
|
82
|
Metaplasia
|
Negative
|
[60]
|
Lippman et al.
|
13cRA
|
1,304
|
Second primary tumor
|
Negative
|
[61]
|
- ATBC, α-Tocoferol, β-Carotene Cancer Prevention Study; CARET, Carotene and Retinol Efficacy Test; ADT, anethole dithioethione (5-[p-methoxyphenyl]-1,2-dithiole-3-thione; 13cRA, 13 cis retinoic acid