Non-protein coding RNA biomarkers and differential expression in cancers: a review

Table 1 Examples of ncRNAs implicated in cancer (from Prasanth and Spector 2007, with added RNA species

Transcript	Organism	Size (nt)	Genome map	Deregulation	Type of cancer	References
Deleted in U2020	human		3p12	Overexpression	Lung, breast, other	[18]
NCRSM	human		12q23.1	Overexpression	rhabdomyosarcoma	[95]
HIS-1	Mouse	3000	2	Overexpression	Myeloid leukemia	[40]
DD3	Human	2000–4300	9q21-22	Overexpression	Prostate	[96]
PCGEM1	Human	1603	2q32	Overexpression	Prostate	[38]
BC200	Human	200	2p16	Overexpression	Breast, parotid, cervix, esophagus, lung, ovary, tongue	[97]
MALAT-1	Human, mouse	8000	11q13	Overexpression	NSCLC	[98, 98]
H19	Human	2700	11p15.5	Loss of imprinting, overexpression	Liver and breast	[33]
21A	Human		CENP-F Antisense	Down-regulation	293T, HeLa	[24]
miR-143	Human	22	5	Down-regulation	Colon	[100]
miR-145	Human	22	5	Down-regulation	Colon	[100]
miR-155/BIC	Human	22	21q21	Overexpression	Burkitt and B cell lymphomas	[71]
miR-15a	Human	22	13q14	Deletion and/or downregulation	B-CLL	[64]
miR-16a	Human	22	13q14	Deletion and/or downregulated	B-CLL	[64]
let-7	Human	21–25	22	Downregulated	Lung adenocarcinoma	[68]
NAMA	Human	873	9q22.33	Downregulated	Papillary thyroid carcinoma	[37]

ISSN: 1756-9966