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Table 1 Combination index values of docetaxel or ATRA alone and their combination on growth inhibition of DU-145 cells.

From: Enhancement of docetaxel-induced cytotoxicity and apoptosis by all-trans retinoic acid (ATRA) through downregulation of survivin (BIRC5), MCL-1 and LTbeta-R in hormone- and drug resistant prostate cancer cell line, DU-145

Concentration of drugs

CI value

 

DOC (0,01 nM) + ATRA (60 μM)

0.254

Strong synergism

DOC (0,1 nM) + ATRA (80 μM)

0.300

Strong synergism

DOC (0,1 nM) + ATRA (60 μM)

0.219

Strong synergism

  1. Combination index (CI) values were calculated from the XTT cell proliferation assays. The data represent the mean + SD of 3 independent experiments.