Parenteral anticoagulation for prolonging survival of patients with cancer | ||||||
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Patient or population: Patients with cancer | ||||||
Settings: Outpatient | ||||||
Intervention: Parenteral anticoagulation | ||||||
Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
Assumed risk | Corresponding risk | |||||
Control | Parenteral anticoagulation | |||||
Survival | Low risk population | HR 0.77 (0.65 to 0.91) | 1174 (5) | ⊕⊕⊕O moderate4 | ||
500 per 1000 | 414 per 1000 (363 to 468) | |||||
Moderate risk population | ||||||
1000 per 1000 | 1000 per 1000 (1000 to 1000) | |||||
DVT | Low risk population | RR 0.61 (0.08 to 4.91) | 458 (2) | ⊕OOO very low1,2 | ||
10 per 1000 | 6 per 1000 (1 to 49) | |||||
High risk population | ||||||
40 per 1000 | 24 per 1000 (3 to 196) | |||||
Major bleeding | Low risk population | RR 1.50 (0.26 to 8.8) | 814 (3) | ⊕⊕OO low1,3 | ||
0 per 1000 | 0 per 1000 (0 to 0) | |||||
High risk population | ||||||
100 per 1000 | 150 per 1000 (26 to 880) | |||||
Minor bleeding | Low risk population | RR 2.07 (0.78 to 5.51) | 760 (3) | ⊕⊕OO low1,3 | ||
0 per 1000 | 0 per 1000 (0 to 0) | |||||
High risk population | ||||||
30 per 1000 | 62 per 1000 (23 to 165) |