Table 1 Expression of Smac/DIABLO in different tumors.

RCC

↓

mRNA.

Expression was low in patients with metastasis progress.

[29]

↓

Protein.

The levels of expression inversely correlate with grade disease.

[30]

-

mRNA and protein.

XIAP-Smac/DIABLO ratio increased from early to advance stages.

[28]

Lung cancer

↓

mRNA.

Patients with low expression had worse prognosis.

[31]

TGCT

↓

mRNA.

Smac/DIABLO expression diminished from normal testicular tissue to non-seminomatous germ cell tumours and stage III tumors.

[34]

HCC

↓

mRNA and protein.

Tissues with HCC primary had low expression of Smac/DIABLO compared with normal organ.

[35]

CC

↑

mRNA.

Smac/DIABLO expression is independent of stage. In a subset of tumors Smac/DIABLO is expressed de novo.

[36]

↑

Protein.

Higher expression in adenocarcinoma than squamous tumors and correlates with a marker of angiogenesis.

There was not any correlation with grade disease or survival rates.

[37]

GA

↑

mRNA.

Smac/DIABLO expression was higher in gastric adenocarcinomas than in non-neoplastic gastric mucosa.

[38]

Lymphomas (NHL and HL)

-

Protein.

There was not difference in Smac/DIABLO expression between clinically indolent and aggressive NHLs.

Ren. Y. et al.*

Carcinomas and sarcomas

-

Protein.

Different tumors had distinct immunoreactivity against Smac/DIABLO.

Yoo, N.J.et al**