Table 2 Genotype distribution in colorectal cancer and Allele frequency
Allele frequency | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Genotype | patients (n = 68) | controls (n = 121) | crude | adjusted | patients | controls | |||||
n | % | n | % | OR (95%CI) | p | OR (95%CI)a | p | % | % | ||
OGG1 | |||||||||||
Ser/Ser | 17 | 25.0 | 39 | 32.2 | 1.00 | 1.00 | Ser | 52.9 | 54.6 | ||
Ser/Cys,Cys/Cys | 51 | 75.0 | 82 | 67.8 | 1.43 (0.73–2.78) | 0.297 | 1.43 (0.69–2.95) | 0.332 | Cys | 47.1 | 45.5 |
MUTYH | |||||||||||
Gln/Gln | 8 | 11.8 | 37 | 30.6 | 1.00 | 1.00 | Gln | 39.0 | 59.1 | ||
Gln/His,His/His | 60 | 88.2 | 84 | 69.4 | 3.30 (1.44–7.60) | 0.005 | 3.53 (1.44–8.70) | 0.006 | His | 61.0 | 40.9 |
APEX1 | |||||||||||
Asp/Asp | 23 | 33.8 | 70 | 57.9 | 1.00 | 1.00 | Asp | 64.0 | 74.8 | ||
Asp/Glu,Glu/Glu | 45 | 66.2 | 51 | 42.1 | 2.69 (1.45–4.99) | 0.002 | 2.33 (1.21–4.48) | 0.011 | Glu | 36.0 | 25.2 |
XRCC1 | |||||||||||
Arg/Arg | 42 | 61.8 | 62 | 51.2 | 1.00 | 1.00 | Arg | 78.7 | 71.1 | ||
Arg/Gln,Gln/Gln | 26 | 38.2 | 59 | 48.8 | 0.65 (0.36–1.19) | 0.164 | 0.60 (0.31–1.15) | 0.125 | Gln | 21.3 | 28.9 |