Table 4 Genotype distribution in relation to smoking status in colorectal cancer
Genotype | non-smokers (Pack-years = 0) | smokers (Pack-years > 0) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
patients (n = 36) | controls (n = 55) | crude | adjusted | Patients (n = 26) | controls (n = 60) | crude | adjusted | |||||||||
n | % | n | % | OR (95%CI) | p | OR (95%CI)a | p | N | % | n | % | OR (95%CI) | p | OR (95%CI)a | p | |
OGG1 | ||||||||||||||||
Ser/Ser | 8 | 22.2 | 14 | 25.5 | 1.00 | 1.00 | 7 | 26.9 | 23 | 38.3 | 1.00 | 1.00 | ||||
Ser/Cys,Cys/Cys | 28 | 77.8 | 41 | 74.5 | 1.20 (0.44–3.23) | 0.725 | 1.14 (0.41–3.13) | 0.807 | 19 | 73.1 | 37 | 61.7 | 1.69 (0.61–4.64) | 0.310 | 1.68 (0.60–4.67) | 0.321 |
MUTYH | ||||||||||||||||
Gln/Gln | 4 | 11.1 | 18 | 32.7 | 1.00 | 1.00 | 3 | 11.5 | 17 | 28.3 | 1.00 | 1.00 | ||||
Gln/His,His/His | 32 | 88.9 | 37 | 67.3 | 3.89 (1.19–12.69) | 0.024 | 4.08 (1.22–13.58) | 0.022 | 23 | 88.5 | 43 | 71.7 | 3.03 (0.80–11.43) | 0.102 | 2.95 (0.77–11.25) | 0.113 |
APEX1 | ||||||||||||||||
Asp/Asp | 15 | 41.7 | 29 | 52.7 | 1.00 | 1.00 | 8 | 30.8 | 41 | 68.3 | 1.00 | 1.00 | ||||
Asp/Glu,Glu/Glu | 21 | 58.3 | 26 | 47.3 | 1.56 (0.67–3.65) | 0.303 | 1.56 (0.66–3.68) | 0.311 | 18 | 69.2 | 19 | 31.7 | 4.86 (1.80–13.13) | 0.002 | 5.02 (1.80–13.99) | 0.002 |
XRCC1 | ||||||||||||||||
Arg/Arg | 20 | 55.6 | 29 | 52.7 | 1.00 | 1.00 | 18 | 69.2 | 30 | 50.0 | 1.00 | 1.00 | ||||
Arg/Gln,Gln/Gln | 16 | 44.4 | 26 | 47.3 | 0.89 (0.38–2.08) | 0.791 | 0.86 (0.37–2.03) | 0.732 | 8 | 30.8 | 30 | 50.0 | 0.44 (0.17–1.18) | 0.103 | 0.43 (0.16–1.16) | 0.097 |