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Table 4 Genotype distribution in relation to smoking status in colorectal cancer

From: Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population

Genotype non-smokers (Pack-years = 0) smokers (Pack-years > 0)
  patients (n = 36) controls (n = 55) crude adjusted Patients (n = 26) controls (n = 60) crude adjusted
  n % n % OR (95%CI) p OR (95%CI)a p N % n % OR (95%CI) p OR (95%CI)a p
OGG1                 
   Ser/Ser 8 22.2 14 25.5 1.00   1.00   7 26.9 23 38.3 1.00   1.00  
   Ser/Cys,Cys/Cys 28 77.8 41 74.5 1.20 (0.44–3.23) 0.725 1.14 (0.41–3.13) 0.807 19 73.1 37 61.7 1.69 (0.61–4.64) 0.310 1.68 (0.60–4.67) 0.321
MUTYH                 
   Gln/Gln 4 11.1 18 32.7 1.00   1.00   3 11.5 17 28.3 1.00   1.00  
   Gln/His,His/His 32 88.9 37 67.3 3.89 (1.19–12.69) 0.024 4.08 (1.22–13.58) 0.022 23 88.5 43 71.7 3.03 (0.80–11.43) 0.102 2.95 (0.77–11.25) 0.113
APEX1                 
   Asp/Asp 15 41.7 29 52.7 1.00   1.00   8 30.8 41 68.3 1.00   1.00  
   Asp/Glu,Glu/Glu 21 58.3 26 47.3 1.56 (0.67–3.65) 0.303 1.56 (0.66–3.68) 0.311 18 69.2 19 31.7 4.86 (1.80–13.13) 0.002 5.02 (1.80–13.99) 0.002
XRCC1                 
   Arg/Arg 20 55.6 29 52.7 1.00   1.00   18 69.2 30 50.0 1.00   1.00  
   Arg/Gln,Gln/Gln 16 44.4 26 47.3 0.89 (0.38–2.08) 0.791 0.86 (0.37–2.03) 0.732 8 30.8 30 50.0 0.44 (0.17–1.18) 0.103 0.43 (0.16–1.16) 0.097
  1. a: OR adjusted for gender, age