The effects of si-CD147 on SMMC-7721 microfilament actin, microtubule and vimentin. After being transfected with negative control or si-CD147 for 48 h, cells were trypsinized and cultured on coverslips, and then fixed. The effects of si-CD147 on SMMC-7721 cytoskeleton were investigated by confocal microscopy. Actin, mirotublin and vimentin filaments in si-CD147 transfected cells were significantly altered (A) and the mean signal intensities were quantified with ImageJ software (B). *P < 0.05 v.s. control.