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Table 1 Expression of p27Kip1, Skp2, and Cks1 in relation to clinicopathological parameters

From: Prognostic implication of p27Kip1, Skp2 and Cks1 expression in renal cell carcinoma: a tissue microarray study

  

P27

Skp2

Cks1

Variables

No.

Low

High

p-value

N

P

p-value

N

P

p-value

Age, years

          

Mean

 

62.5

61.3

0.904

62.0

65.1

0.723

60.0

62.3

0.630

Gender

          

Men

329

213

116

 

281

48

 

272

57

 

Women

153

101

52

0.785

130

23

0.898

120

33

0.266

Metastasis

          

Negative

437

279

158

 

376

61

 

359

78

 

Positive

45

35

10

0.062

35

10

0.136

33

12

0.148

Histology

          

Clear cell

384

239

145

 

316

68

 

302

82

 

Papillary

81

61

20

 

78

3

 

73

8

 

Chromophobe

17

14

3

0.008a

17

0

<0.001a

17

0

0.003a

pT stage

          

1

255

141

114

 

243

12

 

217

38

 

2

103

78

25

 

83

20

 

78

25

 

3+4

124

95

29

0.002b

85

39

<0.001b

97

27

0.304b

Tumor size

          

≤ 7.0

324

188

136

 

298

26

 

273

51

 

>7.0

158

126

32

<0.001

113

45

<0.001

119

39

0.018

Grade

          

1

78

46

32

 

68

10

 

60

18

 

2

250

159

91

 

215

35

 

201

49

 

3

121

86

35

 

102

19

 

103

18

 

4

33

23

10

0.075c

26

7

0.361c

28

5

0.149c

Necrosis

          

Absent

432

271

161

 

376

56

 

352

80

 

Present

50

43

7

0.001

35

15

0.001

40

10

0.799

ECOG-PS

          

= 0

388

250

138

 

335

53

 

313

75

 

>0

94

64

30

0.505

76

18

0.178

79

15

0.452

  1. Note: N indicates negative; P indicates positive;
  2. a Histology, clear cell vs. others.
  3. bStage, Stages I and II vs. Stages III and IV.
  4. c Grade, Grade1/2 vs. Grade3/4.