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Table 1 Expression of p27Kip1, Skp2, and Cks1 in relation to clinicopathological parameters

From: Prognostic implication of p27Kip1, Skp2 and Cks1 expression in renal cell carcinoma: a tissue microarray study

   P27 Skp2 Cks1
Variables No. Low High p-value N P p-value N P p-value
Age, years           
Mean   62.5 61.3 0.904 62.0 65.1 0.723 60.0 62.3 0.630
Gender           
Men 329 213 116   281 48   272 57  
Women 153 101 52 0.785 130 23 0.898 120 33 0.266
Metastasis           
Negative 437 279 158   376 61   359 78  
Positive 45 35 10 0.062 35 10 0.136 33 12 0.148
Histology           
Clear cell 384 239 145   316 68   302 82  
Papillary 81 61 20   78 3   73 8  
Chromophobe 17 14 3 0.008a 17 0 <0.001a 17 0 0.003a
pT stage           
1 255 141 114   243 12   217 38  
2 103 78 25   83 20   78 25  
3+4 124 95 29 0.002b 85 39 <0.001b 97 27 0.304b
Tumor size           
≤ 7.0 324 188 136   298 26   273 51  
>7.0 158 126 32 <0.001 113 45 <0.001 119 39 0.018
Grade           
1 78 46 32   68 10   60 18  
2 250 159 91   215 35   201 49  
3 121 86 35   102 19   103 18  
4 33 23 10 0.075c 26 7 0.361c 28 5 0.149c
Necrosis           
Absent 432 271 161   376 56   352 80  
Present 50 43 7 0.001 35 15 0.001 40 10 0.799
ECOG-PS           
= 0 388 250 138   335 53   313 75  
>0 94 64 30 0.505 76 18 0.178 79 15 0.452
  1. Note: N indicates negative; P indicates positive;
  2. a Histology, clear cell vs. others.
  3. bStage, Stages I and II vs. Stages III and IV.
  4. c Grade, Grade1/2 vs. Grade3/4.