|  | P27 | Skp2 | Cks1 | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Variables | No. | Low | High | p-value | N | P | p-value | N | P | p-value |
Age, years | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Mean | Â | 62.5 | 61.3 | 0.904 | 62.0 | 65.1 | 0.723 | 60.0 | 62.3 | 0.630 |
Gender | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Men | 329 | 213 | 116 | Â | 281 | 48 | Â | 272 | 57 | Â |
Women | 153 | 101 | 52 | 0.785 | 130 | 23 | 0.898 | 120 | 33 | 0.266 |
Metastasis | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Negative | 437 | 279 | 158 | Â | 376 | 61 | Â | 359 | 78 | Â |
Positive | 45 | 35 | 10 | 0.062 | 35 | 10 | 0.136 | 33 | 12 | 0.148 |
Histology | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Clear cell | 384 | 239 | 145 | Â | 316 | 68 | Â | 302 | 82 | Â |
Papillary | 81 | 61 | 20 | Â | 78 | 3 | Â | 73 | 8 | Â |
Chromophobe | 17 | 14 | 3 | 0.008a | 17 | 0 | <0.001a | 17 | 0 | 0.003a |
pT stage | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1 | 255 | 141 | 114 | Â | 243 | 12 | Â | 217 | 38 | Â |
2 | 103 | 78 | 25 | Â | 83 | 20 | Â | 78 | 25 | Â |
3+4 | 124 | 95 | 29 | 0.002b | 85 | 39 | <0.001b | 97 | 27 | 0.304b |
Tumor size | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
≤ 7.0 | 324 | 188 | 136 |  | 298 | 26 |  | 273 | 51 |  |
>7.0 | 158 | 126 | 32 | <0.001 | 113 | 45 | <0.001 | 119 | 39 | 0.018 |
Grade | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1 | 78 | 46 | 32 | Â | 68 | 10 | Â | 60 | 18 | Â |
2 | 250 | 159 | 91 | Â | 215 | 35 | Â | 201 | 49 | Â |
3 | 121 | 86 | 35 | Â | 102 | 19 | Â | 103 | 18 | Â |
4 | 33 | 23 | 10 | 0.075c | 26 | 7 | 0.361c | 28 | 5 | 0.149c |
Necrosis | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Absent | 432 | 271 | 161 | Â | 376 | 56 | Â | 352 | 80 | Â |
Present | 50 | 43 | 7 | 0.001 | 35 | 15 | 0.001 | 40 | 10 | 0.799 |
ECOG-PS | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
= 0 | 388 | 250 | 138 | Â | 335 | 53 | Â | 313 | 75 | Â |
>0 | 94 | 64 | 30 | 0.505 | 76 | 18 | 0.178 | 79 | 15 | 0.452 |