Figure 1From: Hypermethylation of the DPYD promoter region is not a major predictor of severe toxicity in 5-fluorouracil based chemotherapyBSM induced, methylation-specific sequence differences in the DPYD promoter region. Sequence chromatograms of clone inserts originating from methylated and unmethlyated DNA, obtained in the control experiment using enzymatically methylated DNA. Unmethylated cytosines at CpG sites (indicated with black arrows) are converted to thymines, resulting in a sequence change. The two regulatory elements are shown; numbers indicate the sequence position relative to the transcription start site.Back to article page