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Table 1 Grading of acute limb toxicity according to Wieberdink et al.

From: Toxicity and morbility after isolated lower limb perfusion in 242 chemo-hyperthermal treatments for cutaneous melanoma: The experience of the Tuscan Reference Centre

Grade I No subjective or objective evidence of reaction
Grade II Slight erythema and or oedema
Grade III Considerable erythema and/or oedema with some blistering; slightly disturbed motility
Grade IV Extensive epidermolysis and/or obvious damage to the deep tissue, causing definite functional disturbances; threatening or manifest compartiment syndromes
Grade V Severe reaction which may necessitate amputation