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Table 2 Patients' characteristics – protocol schedules.

From: Toxicity and morbility after isolated lower limb perfusion in 242 chemo-hyperthermal treatments for cutaneous melanoma: The experience of the Tuscan Reference Centre

HILP Group   G-A G-B G-C
HT schedule   MILD TRUE TRUE
HILP = n   60 74 108
Period   1984–1989 1988–1994 1990–2007
Gender: M/F   16/44 29/45 29/79
Age: median yrs (range)   55.1 (24–76) 52 (20–70) 60.6 (30–78)
Mean body weigh: kg (range)   68.3 (45/97) 69.8 (50–96) 70 (45–138)
Mean limb volume: lt (range)   10.4 (7.5–14) 11.1 (8.2–16) 10.3 (7.5–20.5)
Stage I-II: HILP = n (%)   34 (56.7) 59 (79.8) 4 (3.7)
Stage III-IV: HILP = n (%)   26 (43.3) 15 (20.2) 104 (96.3)
HT grade   38–40°C 40–41.8°C 40–41.8°C
L-PAM mg/lt limb vol 10 10 10
  mg for 1 lt of prime 10 10 10
  mg/lt limb vol - - 5 (add. bolus)
Mean L-PAM mg (range)   114.1 (85–150) 122.9 (92–195) 163 (120–240)
D-act. 1 mg: HILP = n (%)   10 (16.6) 15 (20.2) 43 (39.8)
First HILP = n (%)   55 (91.7) 70 (94.6) 88 (81.5)
Second HILP = n (%)   5 (8.3) 4 (5.4) 20 (18.5)