Figure 5From: Modulating effect of the PI3-kinase inhibitor LY294002 on cisplatin in human pancreatic cancer cellsAugmentation therapy modulates downstream effecters of Akt to apoptosis. The downstream effects of the Akt pathway were examined by Western blotting. Bad was phosphorylated by cisplatin (5 μmol/L) treatment, while LY294002 (10 μmol/L) inhibited the phosphorylation. Augmentation with LY294002 weakened Bad phosphorylation and increased the cleavage of caspases-3.Back to article page