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Figure 5 | Journal of Experimental & Clinical Cancer Research

Figure 5

From: Modulating effect of the PI3-kinase inhibitor LY294002 on cisplatin in human pancreatic cancer cells

Figure 5

Augmentation therapy modulates downstream effecters of Akt to apoptosis. The downstream effects of the Akt pathway were examined by Western blotting. Bad was phosphorylated by cisplatin (5 μmol/L) treatment, while LY294002 (10 μmol/L) inhibited the phosphorylation. Augmentation with LY294002 weakened Bad phosphorylation and increased the cleavage of caspases-3.

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