Figure 4
From: Silencing of IQGAP1 by shRNA inhibits the invasion of ovarian carcinoma HO-8910PM cells in vitro
indicates that silencing of IQGAP1 inhibited ovarian cancer cell invasion and migration in vitro. (a) Suppression of IQGAP1 hampered transmembrane migration ability of HO-8910PM cells. HO-8910PM-shIQGAP1, HO-8910PM-shRNA negative and un-transfected HO-8910PM cells were seeded onto a Matrigel-coated invasion chamber and the number of invading cells was determined as described before. *, P < 0.05 versus HO-8910PM-shRNA negative or un-transfected HO-8910PM cells. (b) Suppression of IQGAP1 decreased migration of HO-8910PM cells. HO-8910PM-shIQGAP1, HO-8910PM-shRNA negative and un-transfected HO-8910PM cells were seeded onto a Boyden chamber and the number of migrating cells was determined as described before. *, P < 0.05 versus HO-8910PM-shRNA negative or un-transfected HO-8910PM cells.