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Table 4 Studies of prophylactic cranial irradiation for patients with locally advanced non-small cell lung cancer in recursive partitioning analysis group 1.

From: Prophylactic cranial irradiation in locally advanced non-small cell lung cancer: outcome of recursive partitioning analysis group 1 patients

Reference N patients Histology Primary Tx Dose of PCI BM PCI- (%) BM PCI+ (%) P-value
Albain et al.1 126 All NSCLC Trimodality 36 Gy (2 Gy/fr) 16 8 0.36
Strauss et al.4 54 Non-squamous Trimodality 30 Gy (2 Gy/fr) 12 0 0.32
Skarin et al.12 41 All NSCLC Trimodality NS 27 14  
Rusch et al.11 75 NS Ctx+TRT 36 Gy (2 Gy/fr)
30 Gy (3 Gy/fr)
- 0 -
Stuschke et al.10 75 All NSCLC Trimodality 30 Gy (2 Gy/fr) 54 13 0.0004
Cox et al.5 281 All NSCLC TRT 20 Gy (2 Gy/fr) 13 6 0.038
Unsawasdi.7 97 All NSCLC Trimodality Ctx+TRT 30 Gy (3 Gy/fr) 27 4 0.002
Russell et al.6 187 Non-squamous TRT 30 Gy (3 Gy/fr) 19 9 0.06
Mira et al.32 111 All NSCLC Ctx + TRT 30 Gy (2 Gy/fr)
37.5 Gy (2.5Gy/fr)
11 0 0.0001
Pöttgen et al.14 112 All NSCLC (Stage IIIA) Trimodality 30 Gy (2 Gy/fr) 27.2 9.1 0.02
0.04
Yavuz et al.* 62 Squamous and adeno ca (Stage IIIB) Ctx + TRT 30 Gy (2 Gy/fr) - 9.7 -
  1. (*) Current study.
  2. Abbreviations: Tx = treatment; NSCLC = non-small cell lung cancer, Ctx = chemotherapy, TRT = thoracic radiotherapy; PCI = prophylactic cranial irradiation, BM = brain metastasis.