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Table 4 Studies of prophylactic cranial irradiation for patients with locally advanced non-small cell lung cancer in recursive partitioning analysis group 1.

From: Prophylactic cranial irradiation in locally advanced non-small cell lung cancer: outcome of recursive partitioning analysis group 1 patients

Reference

N patients

Histology

Primary Tx

Dose of PCI

BM PCI- (%)

BM PCI+ (%)

P-value

Albain et al.1

126

All NSCLC

Trimodality

36 Gy (2 Gy/fr)

16

8

0.36

Strauss et al.4

54

Non-squamous

Trimodality

30 Gy (2 Gy/fr)

12

0

0.32

Skarin et al.12

41

All NSCLC

Trimodality

NS

27

14

 

Rusch et al.11

75

NS

Ctx+TRT

36 Gy (2 Gy/fr)

30 Gy (3 Gy/fr)

-

0

-

Stuschke et al.10

75

All NSCLC

Trimodality

30 Gy (2 Gy/fr)

54

13

0.0004

Cox et al.5

281

All NSCLC

TRT

20 Gy (2 Gy/fr)

13

6

0.038

Unsawasdi.7

97

All NSCLC

Trimodality Ctx+TRT

30 Gy (3 Gy/fr)

27

4

0.002

Russell et al.6

187

Non-squamous

TRT

30 Gy (3 Gy/fr)

19

9

0.06

Mira et al.32

111

All NSCLC

Ctx + TRT

30 Gy (2 Gy/fr)

37.5 Gy (2.5Gy/fr)

11

0

0.0001

Pöttgen et al.14

112

All NSCLC (Stage IIIA)

Trimodality

30 Gy (2 Gy/fr)

27.2

9.1

0.02

0.04

Yavuz et al.*

62

Squamous and adeno ca (Stage IIIB)

Ctx + TRT

30 Gy (2 Gy/fr)

-

9.7

-

  1. (*) Current study.
  2. Abbreviations: Tx = treatment; NSCLC = non-small cell lung cancer, Ctx = chemotherapy, TRT = thoracic radiotherapy; PCI = prophylactic cranial irradiation, BM = brain metastasis.