Table 3 Genotype distribution in relation to histological type in lung cancer
Genotype | Adenocarcinoma | Squamous Cell Carcinoma | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
patients (n = 67) | controls (n = 121) | crude | adjusted | patients (n = 31) | controls (n = 121) | crude | adjusted | |||||||||
n | % | n | % | OR (95%CI)a | P-value | OR (95%CI)a | P-value | n | % | n | % | OR (95%CI)a | P-value | OR (95%CI)a | P-value | |
OGG1 | ||||||||||||||||
Ser/Ser | 17 | 25.4 | 39 | 32.2 | 1.00 | 1.00 | 8 | 25.8 | 39 | 32.3 | 1.00 | 1.00 | ||||
Ser/Cys | 33 | 49.2 | 54 | 44.6 | 1.40 (0.69–2.87) | 0.355 | 1.34 (0.64–2.81) | 0.439 | 16 | 51.6 | 54 | 44.6 | 1.44 (0.56–3.71) | 0.445 | 1.23 (0.44–3.43) | 0.695 |
Cys/Cys | 17 | 25.4 | 28 | 23.1 | 1.39 (0.61–3.19) | 0.434 | 1.31 (0.56–3.08) | 0.530 | 7 | 22.6 | 28 | 23.1 | 1.22 (0.40–3.75) | 0.730 | 1.54 (0.45–5.23) | 0.491 |
MUTYH | ||||||||||||||||
Gln/Gln | 13 | 19.4 | 37 | 30.6 | 1.00 | 1.00 | 6 | 19.4 | 37 | 30.6 | 1.00 | 1.00 | ||||
Gln/His | 38 | 56.7 | 69 | 57.0 | 1.57 (0.74–3.30) | 0.237 | 1.55 (0.72–3.32) | 0.263 | 15 | 48.4 | 69 | 57.0 | 1.34 (0.48–3.75) | 0.576 | 1.00 (0.33–3.01) | 0.999 |
His/His | 16 | 23.9 | 15 | 12.4 | 3.04 (1.18–7.82) | 0.021 | 2.50 (0.95–6.62) | 0.065 | 10 | 32.3 | 15 | 12.4 | 4.11 (1.27–13.33) | 0.019 | 3.20 (0.89–11.49) | 0.075 |