Table 4 Genotype distribution in relation to smoking status in lung cancer
Non-smokers | Smokers | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Genotype | (Pack-years = 0) | (Pack-years > 0) | ||||||||||||||
patients (n = 32) | controls (n = 55) | crude | adjusted | patients (n = 74) | controls (n = 60) | crude | adjusted | |||||||||
n | % | n | % | OR (95%CI)a | P-value | OR (95%CI)a | P-value | n | % | n | % | OR (95%CI)a | P-value | OR (95%CI)a | P-value | |
OGG1 | ||||||||||||||||
Ser/Ser | 5 | 15.6 | 14 | 25.5 | 1.00 | 1.00 | 20 | 27.0 | 23 | 38.3 | 1.00 | 1.00 | ||||
Ser/Cys | 20 | 62.5 | 26 | 47.3 | 2.15 (0.67–6.98) | 0.201 | 2.49 (0.72–8.57) | 0.148 | 35 | 47.3 | 25 | 41.7 | 1.61 (0.73–3.54) | 0.237 | 1.53 (0.69–3.40) | 0.292 |
Cys/Cys | 7 | 21.9 | 15 | 46.9 | 1.31 (0.34–5.09) | 0.700 | 1.38 (0.34–5.64) | 0.654 | 19 | 25.7 | 12 | 20.0 | 1.82 (0.71–4.66) | 0.211 | 1.81 (0.70–4.65) | 0.219 |
MUTYH | ||||||||||||||||
Gln/Gln | 5 | 15.6 | 18 | 32.7 | 1.00 | 1.00 | 17 | 23.0 | 17 | 28.3 | 1.00 | 1.00 | ||||
Gln/His | 19 | 59.4 | 28 | 50.9 | 2.44 (0.77–7.71) | 0.128 | 2.06 (0.63–6.76) | 0.233 | 36 | 48.6 | 37 | 61.7 | 0.97 (0.43–2.20) | 0.947 | 1.07 (0.47–2.46) | 0.867 |
His/His | 8 | 25.0 | 9 | 16.4 | 3.20 (0.81–12.65) | 0.097 | 2.60 (0.60–11.25) | 0.200 | 21 | 28.4 | 6 | 10.0 | 3.50 (1.13–10.83) | 0.030 | 3.82 (1.22–12.00) | 0.022 |