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Table 6 Representation of genetic association of the SNP rs13181 in the gene ERCC2 with the risk of SCCHN among north Indians determined in terms of odds ratios of mutant genotypes.

From: Statistically significant association of the single nucleotide polymorphism (SNP) rs13181 (ERCC2) with predisposition to Squamous Cell Carcinomas of the Head and Neck (SCCHN) and Breast cancer in the north Indian population

Genotype

OR

95% CI (OR)

P Value

ORa

95% CI (ORa)

ORb

95% CI (ORb)

WM (AC)

1.531

1.092 to 2.149

0.0167

1.536

.816

2.892

1.297

.712

2.363

MM (CC)

1.680

1.014 to 2.784

0.0497

1.778

.692

4.567

1.446

.598

3.496

WM + MM (AC+CC)

1.560

1.128 to 2.158

0.0073

1.583

0.864

2.900

1.327

0.749

2.353

  1. [CI-Confidence Interval; OR-Odds Ratio; WW-homozygous wild type; WM-heterozygous; MM-homozygous mutant; WM + MM-combined mutant genotype
  2. WW was considered as the referent category during the calculation of ORs.
  3. An OR >1 denotes positive association, while OR <1 signifies protective/negative association with cancer risk. ORa-Adjusted Odds Ratio for Gender, ORb-Adjusted Odds Ratio for Smoking, Tobacco chewing and Pan Masala]