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Table 3 The down-regulated DEGs sharing from cirrhosis to metastasis sorted out by the following GO function.

From: Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model

Gene Symbol

Gene Title

GO

COL18A1

procollagen, type XVIII, alpha 1

1–6

CXCL12

chemokine (C-X-C motif) ligand 12

1,2,4,5

KDR

kinase insert domain protein receptor

1,4,6

SERPINA3K

serine (or cysteine) peptidase inhibitor, clade A, member 3K

1,2,5

ANG1

angiogenin, ribonuclease A family, member 1

1,5

RNASE4

ribonuclease, RNase A family 4

1,5

C5

complement component 5

2,4

CML4

Camello-like 4

3

ENPP2

ectonucleotide pyrophosphatase/phosphodiesterase 2

3

GPHN

gephyrin

3

IGFALS

insulin-like growth factor binding protein, acid labile subunit

3

LIN7A

lin-7 homolog a (C. elegans)

3

AZGP1

alpha-2-glycoprotein 1, zinc

3,5

PROC

Protein C

2

PTPRD

protein tyrosine phosphatase, receptor type, D

3

PVRL3_predicted

poliovirus receptor-related 3 (predicted)

3

SORL1

sortilin-related receptor, LDLR class A repeats-containing

4,5

TGFBI

transforming growth factor, beta induced

3,4,6

RB1

retinoblastoma 1

2,3,5

EGFR

epidermal growth factor receptor

2–6

EGF

epidermal growth factor

2,5,6

IGF1

Insulin-like growth factor 1

2,5,6

HNF4A

Hepatocyte nuclear factor 4, alpha

2,5

BCL6_PREDICTED

B-cell leukemia 6 (predicted)

2,5

PEMT

phosphatidylethanolamine N-methyltransferase

2,5

LRP1

low density lipoprotein receptor-related protein 1

2,5

RGN

regucalcin

2,5

SGPP1

sphingosine-1-phosphate phosphatase 1

2

NR1D2

nuclear receptor subfamily 1, group D, member 2

2

GHR

Growth hormone receptor

2

CYP2E1

cytochrome P450, family 2, subfamily e, polypeptide 1

2

C4BPB

complement component 4 binding protein, beta

2

C6

complement component 6

2

FAAH

fatty acid amide hydrolase

2

NR0B2

nuclear receptor subfamily 0, group B, member 2

2

PCSK9

proprotein convertase subtilisin/kexin type 9

2

UNG

uracil-DNA glycosylase

2

CEBPA

CCAAT/enhancer binding protein (C/EBP), alpha

5

PCAF

p300/CBP-associated factor

5

CFB

complement factor B

5

DBP

D site albumin promoter binding protein

5

ADRA1B

adrenergic receptor, alpha 1b

5

FABP1

fatty acid binding protein 1, liver

5

VIPR1

vasoactive intestinal peptide receptor 1

5

ID4

Inhibitor of DNA binding 4

5

NOX4

NADPH oxidase 4

5

AMY1

amylase 1, salivary

6

GPLD1

glycosylphosphatidylinositol specific phospholipase D1

6

SMOC1

SPARC-related modular calcium binding protein 1

6

  1. NOTE: The numbers from 1–6 indicate GO terms: angiogenesis, apoptosis, cell adhesion, cell migration, cell proliferation and extracellular matrix, respectively.