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Table 4 The up-regulated DEGs sharing from cirrhosis to metastasis stage relating to the following GO process.

From: Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model

Gene symbol

Gene name

GO

CCL21B

chemokine (C-C motif) ligand 21b (serine)

1–2

CD276

CD276 antigen

1–2

SPP1

secreted phosphoprotein 1

1–2

CD24

CD24 antigen

1

C1QG

complement component 1, q subcomponent, gamma polypeptide

1

CD74

CD74 antigen

1

HLA-DMA

major histocompatibility complex, class II, DM alpha

1

HLA-DMB

major histocompatibility complex, class II, DM beta

1

DEFB1

defensin beta 1

1

FCGR3

Fc receptor, IgG, low affinity III

1

PLSCR1

phospholipid scramblase 1

1

PRNP

prion protein

1

RT1-BA

RT1 class II, locus Ba

1

RT1-CE5

RT1 class I, CE5

1

RT1-DA

RT1 class II, locus Da

1

RT1-DB1

RT1 class II, locus Db1

1

RT1-BB

RT1 class II, locus Bb

1

ANXA1

annexin A1

2

FABP4

fatty acid binding protein 4, adipocyte

2

S100A8

S100 calcium binding protein A8

2

S100A9

S100 calcium binding protein A9

2

CDC2A

cell division cycle 2 homolog A

3

EGR1

early growth response 1

3

CRYAB

crystallin, alpha B

3

CCND1

cyclin D1

3

CD36

cd36 antigen

3

GCLC

glutamate-cysteine ligase, catalytic subunit

3

GGT1

gamma-glutamyltransferase 1

3

GPX2

glutathione peroxidase 2

3

GPX3

glutathione peroxidase 3

3

GSR

glutathione reductase

3

GSS

glutathione synthetase

3

HSPCB

heat shock 90 kDa protein 1, beta

3

LAMC1

laminin, gamma 1

3

MTAP2

microtubule-associated protein 2

3

NOL3

nucleolar protein 3 (apoptosis repressor with CARD domain)

3

NQO1

NAD(P)H dehydrogenase, quinone 1

3

PDLIM1

PDZ and LIM domain 1 (elfin)

3

SLC25A4

solute carrier family 25

3

TXNRD1

thioredoxin reductase 1

3

  1. NOTE: The numbers from 1–3 indicate immune response, inflammatory response and oxidative stress, respectively.