Table 1 Dose-Reduction Criteria and Dose to be selected at Dose-Reduction
Item | Oxaliplatin | 5-FU (bolus) | 5-FU (infusion) | |
|---|---|---|---|---|
Neutrophil count | < 500/mm 3 | 85 → 85 | 400 → 0 | 2,400 → 2,400 |
Platelet count | < 50,000/mm 3 | 85 → 85 | 400 → 0 | 2,400 → 2,400 |
Non-hematological toxicity | ≥ Grade 3 | 85 → 65 | 400 → 300 | 2,400 → 2,000 |
Skin symptoms | ≥ Grade 3 | 85 → 85 | 400 → 300 | 2,400 → 2,000 |
Peripheral neuropathy | Grade 2 | 85 → 65 | 400 → 400 | 2,400 → 2,400 |
Acute* 1 laryngopharyngeal dysesthesia (feeling of difficulty in breathing) | 85 → 85 Infusion time is prolonged to 6 hours* 2 | 400 → 400 | 2,400 → 2,400 | |
Peripheral neuropathy | ≥ Grade 3 | Discontinuation | ||
PS | ≥ 3 | Discontinuation |