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Table 1 Studies included in the analysis including first author, year of publication, type of trial and combined therapy, and pulmonary adverse reactions.

From: Association of cetuximab with adverse pulmonary events in cancer patients: a comprehensive review

Number

Ref:

Author

Year

Study Type

Cancer Type

Combined Agents

Pulmonary Reactions

1

51

Vermorken

2008

Phase II

SCCHN

platinum

dyspnea, Pneumonia

2

29

Koo

2007

Phase II

Colorectal

FOLFIRI, irinotecan

dyspnea

3

8

Leard

2007

case

SCCHN

 

DAD

4

16

Burtness

2005

Phase III

SCCHN

cisplatin

dyspnea, hypoxia

5

15

Bourhis

2006

Phase I/II

SCCHN

cisplatin, carboplatin/5-fluorouracil

respiratory symptoms

6

12

Baselga

2005

Phase II

SCCHN

platinum

respiratory disorder

7

50

Vermorken

2007

review

SCCHN

cisplatinum, carboplatin

dyspnea, infusion rxn

8

20

Cunningham

2004

Prospective

Colorectal

irinotecan

dyspnea

9

53

Xiong

2004

Phase II

Pancreatic

gemcitabine

Pneumonia, Sepsis, PE, Pulm Insufficeincy

10

19

Chan

2005

Phase II

Nasopharyngeal

carboplatin

Pleural Effusion, Dyspnea, Pneumonia

11

40

Robert

2005

Phase I/II

NSCLC

gemcitibine, carboplatin

Pulmonary Embolism

12

23

Hanna

2006

Phase II

NSCLC

 

Dyspnea

13

54

Zhu

2007

Phase II

HCC

 

Cough

14

31

Machiels

2007

Phase I/II

Colorectal

capecitabine, ExBR

Pulmonary Embolism, Pulm Infetion

15

13

Bonner

2006

RCT

SCCHN

ExBR

cough, increased sputum

16

32

Martin-Martorell

2008

Phase II

Colorectal

irinotecan

none

17

28

Konner

2008

Phase II

Ovarian

carboplatin, paclitaxel

Dyspnea

18

56

Hughes

2008

Phase I/II

NSCLC

platinum, ExBR 64 Gy

dyspnea, pneumonitis, pulm embolism, pneumonia

19

11

Asnacios

2008

Phase II

HCC

oxaliplatin, gemcitabine

none

20

18

Cascinu

2008

Phase II

Pancreatic

cisplatin, gemcitabine

none

21

35

Paule

2007

Phase II

Cholangiocarcinoma

oxaliplatin, gemcitabine

none

22

47

Tabernero

2007

Phase II

Colorectal

oxaliplatin, 5-fluorouracil

Dyspnea

23

27

Jonker

2007

rescue

Colorectal

prev-oxal, irinotecan, flouropyrimidine

dyspnea

24

42

Safran

2008

phase II

Espohageal

carboplatin, paclitaxel, ExBR

Pneumonia

25

26

Ibrahim

2007

phase II

Colorectal

oxaliplatin, irinotecan

none

26

38

Pinto

2007

phase II

Gastric/GE

irinotecan, 5-fluorouracil

none

27

46

Souglakos

2007

phase II

Colorectal

oxaliplatin, capecitabine

none

28

30

Lenz

2006

phase II

Colorectal

prev-oxaloplatin, irinotecan, flouropyrimidine

none

29

25

Hofheinz

2006

phase I

Colorectal

capecitabine, irinotecan, ExBR

none

30

24

Herbst

2005

phase II

SCCHN

cisplatin

none

31

43

Saltz

2004

phase II

Colorectal

previous irinotecan

none

32

52

Vincenzi

2006

phase II

Colorectal

irinotecan

none

33

37

Pfister

2006

phase II

SCCHN

cisplatin, ExBR

pneumonia

34

39

Robert

2001

phase I

SCCHN

ExBR

none

35

48

Thienelt

2005

Phase I/II

NSCLC

carboplatin, paclitaxel

pulmonary embolism

36

34

Neyns

2008

Phase II

Colorectal

oxaloplatin or irinotecan

Interstitial pneumonitis

37

10

Arnold

2008

Phase Ib/II

Colorectal

oxaliplatin, 5-fluorouracil

None

38

45

Sobrero

2008

Phase III

Colorectal

irinotecan

None

39

44

Secord

2008

Phase II

Ovarian

carboplatin

Pulmonary rxn

40

14

Borner

2008

Phase II

Colorectal

oxaliplatin, capecitabine

none

41

21

Gamucci

2008

Phase II

Colorectal

irinotecan

none

42

49

Tol

2008

Phase III

Colorectal

capecitabine, Oxaliplatin + Bevacizumab

Pulmonary embolism, Respiratory Insuffiency

43

17

Butts

2007

Phase II

NSCLC

gemcitabine, Cisplatin, Carboplatin

dyspnea, Cough, Pneumonia

44

36

Pessino

2008

Phase II

Colorectal

none

none

45

5

Rosell

2008

Phase II

NSCLC

cisplatin, vinorelbine

resp symptoms

46

41

Rodel

2008

Phase I/II

Colorectal

capecitabine, ExBR, Oxaliplatin

none

47

33

Modi

2006

Phase I

Breast

paclitaxel

none

48

22

Gebbia

2006

retrospect rev

Colorectal

irinotecan

none

49

58

Pirker

2009

Phase III

NSCLC

cisplatin, vinorelbine

dyspnea, respiratory failure, pulmonary embolism

50

57

Belani

2008

Phase II

NSCLC

carboplatin, docetaxel

none

51

55

Gridelli

2009

Phase II

NSCLC

gemcitibine

pulmonary symptoms

52

59

Shin

2001

Phase I

SSCHN

Cisplatin

Shortness of Breath

53

60

Baselga

2000

Phase I

SSCHN/NSCLC

Cisplatin

Dyspnea

  1. (Abbreviations: SCCHN - squamous cell cancer of the head and neck, NSCLC - non-small cell lung cancer, ExBR - external beam radiation)