Skip to main content

Table 1 Studies included in the analysis including first author, year of publication, type of trial and combined therapy, and pulmonary adverse reactions.

From: Association of cetuximab with adverse pulmonary events in cancer patients: a comprehensive review

Number Ref: Author Year Study Type Cancer Type Combined Agents Pulmonary Reactions
1 51 Vermorken 2008 Phase II SCCHN platinum dyspnea, Pneumonia
2 29 Koo 2007 Phase II Colorectal FOLFIRI, irinotecan dyspnea
3 8 Leard 2007 case SCCHN   DAD
4 16 Burtness 2005 Phase III SCCHN cisplatin dyspnea, hypoxia
5 15 Bourhis 2006 Phase I/II SCCHN cisplatin, carboplatin/5-fluorouracil respiratory symptoms
6 12 Baselga 2005 Phase II SCCHN platinum respiratory disorder
7 50 Vermorken 2007 review SCCHN cisplatinum, carboplatin dyspnea, infusion rxn
8 20 Cunningham 2004 Prospective Colorectal irinotecan dyspnea
9 53 Xiong 2004 Phase II Pancreatic gemcitabine Pneumonia, Sepsis, PE, Pulm Insufficeincy
10 19 Chan 2005 Phase II Nasopharyngeal carboplatin Pleural Effusion, Dyspnea, Pneumonia
11 40 Robert 2005 Phase I/II NSCLC gemcitibine, carboplatin Pulmonary Embolism
12 23 Hanna 2006 Phase II NSCLC   Dyspnea
13 54 Zhu 2007 Phase II HCC   Cough
14 31 Machiels 2007 Phase I/II Colorectal capecitabine, ExBR Pulmonary Embolism, Pulm Infetion
15 13 Bonner 2006 RCT SCCHN ExBR cough, increased sputum
16 32 Martin-Martorell 2008 Phase II Colorectal irinotecan none
17 28 Konner 2008 Phase II Ovarian carboplatin, paclitaxel Dyspnea
18 56 Hughes 2008 Phase I/II NSCLC platinum, ExBR 64 Gy dyspnea, pneumonitis, pulm embolism, pneumonia
19 11 Asnacios 2008 Phase II HCC oxaliplatin, gemcitabine none
20 18 Cascinu 2008 Phase II Pancreatic cisplatin, gemcitabine none
21 35 Paule 2007 Phase II Cholangiocarcinoma oxaliplatin, gemcitabine none
22 47 Tabernero 2007 Phase II Colorectal oxaliplatin, 5-fluorouracil Dyspnea
23 27 Jonker 2007 rescue Colorectal prev-oxal, irinotecan, flouropyrimidine dyspnea
24 42 Safran 2008 phase II Espohageal carboplatin, paclitaxel, ExBR Pneumonia
25 26 Ibrahim 2007 phase II Colorectal oxaliplatin, irinotecan none
26 38 Pinto 2007 phase II Gastric/GE irinotecan, 5-fluorouracil none
27 46 Souglakos 2007 phase II Colorectal oxaliplatin, capecitabine none
28 30 Lenz 2006 phase II Colorectal prev-oxaloplatin, irinotecan, flouropyrimidine none
29 25 Hofheinz 2006 phase I Colorectal capecitabine, irinotecan, ExBR none
30 24 Herbst 2005 phase II SCCHN cisplatin none
31 43 Saltz 2004 phase II Colorectal previous irinotecan none
32 52 Vincenzi 2006 phase II Colorectal irinotecan none
33 37 Pfister 2006 phase II SCCHN cisplatin, ExBR pneumonia
34 39 Robert 2001 phase I SCCHN ExBR none
35 48 Thienelt 2005 Phase I/II NSCLC carboplatin, paclitaxel pulmonary embolism
36 34 Neyns 2008 Phase II Colorectal oxaloplatin or irinotecan Interstitial pneumonitis
37 10 Arnold 2008 Phase Ib/II Colorectal oxaliplatin, 5-fluorouracil None
38 45 Sobrero 2008 Phase III Colorectal irinotecan None
39 44 Secord 2008 Phase II Ovarian carboplatin Pulmonary rxn
40 14 Borner 2008 Phase II Colorectal oxaliplatin, capecitabine none
41 21 Gamucci 2008 Phase II Colorectal irinotecan none
42 49 Tol 2008 Phase III Colorectal capecitabine, Oxaliplatin + Bevacizumab Pulmonary embolism, Respiratory Insuffiency
43 17 Butts 2007 Phase II NSCLC gemcitabine, Cisplatin, Carboplatin dyspnea, Cough, Pneumonia
44 36 Pessino 2008 Phase II Colorectal none none
45 5 Rosell 2008 Phase II NSCLC cisplatin, vinorelbine resp symptoms
46 41 Rodel 2008 Phase I/II Colorectal capecitabine, ExBR, Oxaliplatin none
47 33 Modi 2006 Phase I Breast paclitaxel none
48 22 Gebbia 2006 retrospect rev Colorectal irinotecan none
49 58 Pirker 2009 Phase III NSCLC cisplatin, vinorelbine dyspnea, respiratory failure, pulmonary embolism
50 57 Belani 2008 Phase II NSCLC carboplatin, docetaxel none
51 55 Gridelli 2009 Phase II NSCLC gemcitibine pulmonary symptoms
52 59 Shin 2001 Phase I SSCHN Cisplatin Shortness of Breath
53 60 Baselga 2000 Phase I SSCHN/NSCLC Cisplatin Dyspnea
  1. (Abbreviations: SCCHN - squamous cell cancer of the head and neck, NSCLC - non-small cell lung cancer, ExBR - external beam radiation)