Polymorphisms of TP53 codon 72 with breast carcinoma risk: evidence from 12226 cases and 10782 controls

Table 3 Main results of the pooled data in the meta-analysis

	No. of cases/controls	Arg/Arg vs Pro/Pro			(Arg/Arg+Arg/Pro) vs Pro/Pro			Arg/Arg vs (Arg/Pro+Pro/Pro)
		OR (95%CI)	P	P (Q-test)	OR (95%CI)	P	P (Q-test)	OR (95%CI)	P	P (Q-test)
Random-effect model
Total	12226/10782	1.20 (0.96–1.50)	0.11	0.000	1.12 (0.96–1.32)	0.14	0.01	1.13 (0.98–1.31)	0.10	0.000
Caucasian	11549/9830	1.15 (0.91–1.44)	0.24	0.001	1.11 (0.95–1.30)	0.17	0.06	1.09 (0.93–1.27)	0.28	0.000
Asian	631/873	1.36 (0.61–3.03)	0.45	0.000	1.19 (0.67–2.10)	0.55	0.006	1.22 (0.72–2.05)	0.46	0.002
African	46/79	1.46 (0.38–5.62)	0.58	0.76	1.12 (0.31–4.10)	0.86	0.45	1.60 (0.63–4.06)	0.32	0.22
Fixed-effect model
Total	12226/10782	1.09 (0.99–1.20)	0.10	0.000	1.09 (0.99–1.19)	0.06	0.01	1.04 (0.99–1.10)	0.13	0.000
Caucasian	11549/9830	1.07 (0.96–1.18)	0.24	0.001	1.08 (0.98–1.19)	0.12	0.06	1.03 (0.98–1.09)	0.25	0.000
Asian	631/873	1.27 (0.94–1.71)	0.12	0.000	1.16 (0.89–1.51)	0.26	0.006	1.15 (0.92–1.44)	0.22	0.002
African	46/79	1.47 (0.39–5.62)	0.57	0.76	1.17 (0.33–4.14)	0.80	0.45	1.67 (0.80–3.48)	0.17	0.22

ISSN: 1756-9966