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Table 3 Factors influencing RDI (above the Median): Univariate and Multivariate analysis

From: Impact of relative dose intensity (RDI) in CHOP combined with rituximab (R-CHOP) on survival in diffuse large B-cell lymphoma

  Univariate model Multivariate model 1 Multivariate model 2
Factor OR (95%CI) P value OR (95%CI) P value OR (95%CI) P value
Age (61 ≤) 0.3(0.2–0.8) 0.0099* 0.4 (0.2–0.8) 0.06 0.4 (0.2–0.8) 0.02*
Sex (male) 1.3 (0.6–2.9) 0.54 - - - -
Stage III, IV 0.8 (0.4–1.9) 0.68 - - - -
Extranodal site (2 ≤) 1.0 (0.4–2.3) 1.00 - - - -
LDH (> upper normal limit) 0.5 (0.2–1.2) 0.11 - - 0.6 (0.3–1.4) 0.24
Performance status (2–4) 0.6 (0.2–1.5) 0.24 - - - -
IPI (high/high intermediate) 0.4 (0.2–1.0) 0.04* 0.6 (0.3–1.6) 0.33 - -
Alb (3.5 mg/dl >) 0.8 (0.5–1.4) 0.50 - - - -
Prophylactic G-CSF + 1.7 (0.7–3.8) 0.22 - - - -
  1. IPI: international prognostic index. G-CSF: granulocyte colony-stimulating factor