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Table 2 Effects of each drug on cell cycle in HT29 cell

From: MMP7 expression regulated by endocrine therapy in ERβ-positive colon cancer cells

Group

G1 (%)

G2/M (%)

S (%)

Control

82.2 ± 5.4

2.2 ± 0.5

15.5 ± 1.8

TAM (M)

10-7

75.9 ± 5.7

9.1 ± 2.1

15 ± 2.5

 

10-6

75.8 ± 4.5

9.2 ± 1.9

15 ± 2.1

 

10-5

63.2 ± 5.1

7.3 ± 1.4

29.5 ± 3.4

 

10-4

30 ± 5.6

2.4 ± 0.6

67.6 ± 4.5

5-FU (μM)

6.25

66.7 ± 5.4

0

33.3 ± 3.8

 

12.5

71.1 ± 6.2

0

28.9 ± 4.2

 

25

73.7 ± 7.4

0

26.3 ± 3.2

 

50

79.8 ± 7.7

0

20.2 ± 3.1

12.5 μM 5-FU +TAM (M)

10-7

75.0 ± 8.1

0

25.0 ± 4.2

 

10-6

67.8 ± 6.3

0

32.2 ± 3.1

 

10-5

51.8 ± 5.5

0

48.2 ± 4.7

  1. Each value is the mean ± SD of three separate experiments.