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Table 4 The sensitivity and specificity of EYA4 and hTERT mRNA expression

From: Relationship between the expression of hTERT and EYA4 mRNA in peripheral blood mononuclear cells with the progressive stages of carcinogenesis of the esophagus

   ESCC ESCD BCH
item Cut off
level
Sensitivity
(%)
Specificity
(%)
Sensitivity
(%)
Specificity
(%)
Sensitivity
(%)
Specificity
(%)
hTERT        
  ≥ 0.3 96.0 5.0 98.0 5.0 98.0 5.0
  0.5- 88.0 19.0 93.0.0 22.0 90.0 22.0
  1.0- 60.0 72.0 48.0 72.0 31.0 72.0
  1.5- 12.0 94.4 12.0 90.0 5.0 90.0
  AUC 0.820 0.671 0.566
EYA4        
  ≥ 0.20 76.0 64.0 36.0 64.0 12.0 64
  0.30- 40.0 73.0 27.0 73.0 0.0 73
  0.40- 20.0 90.0 10.0 90.0 0.0 90
  0.47- 16.0 100.0 4.0 100.0 0.0 100.0
  AUC 0.693 0.553 0.520
  1. NOTE. AUC:area under curve. The cut-off levels (the band intensity ratios of hTER or EYA4 to β-actin) written in bold are the cut-off points that used in the discriminating between positive and negative status with different markers. BCH, Basal cell hyperplasia; ESCD, esophageal squamous cells dyspalsia; ESCC, esophageal squamous cells cancer.