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Table 1 Experimental lung metastasis in syngeneic mice after intravenous injection of B16 melanoma or F3II mammary carcinoma cells, preincubated or not with NeuGc-rich BSM.

From: Exogenous incorporation of neugc-rich mucin augments n-glycolyl sialic acid content and promotes malignant phenotype in mouse tumor cell lines

Treatment

Lung metastasisA

(nodules per animal)

 

B16 cells

F3II cells

Control

6.4 ± 2.2

6.2 ± 2.1

BSM-preincubated

11.6 ± 1.5*

13.3 ± 3.1*

  1. ALung nodules were counted 22 days after intravenous injection of B16 or F3II cells (1 × 105 cells/mouse). Values represent mean ± SEM of at least 10 mice.
  2. *p < 0.05 versus the respective control (Mann-Whitney U test).