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Figure 4 | Journal of Experimental & Clinical Cancer Research

Figure 4

From: The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells

Figure 4

Effect of HIF-1alpha and SOCS1 on cell growth was measured by cell counting. (A) After transfection with Ad5-SOCS1, the growth of cells was slowed but promoted after transfection with Ad5-siSOCS1(* p < 0.05 Ad5-siSOCS1 group vs. Ad5 group; ** p < 0.01 Ad5-SOCS1 group vs. Ad5 group) (B) After transfection with Ad5- HIF-1alpha, the growth of cells was promoted but slowed after transfection with Ad5- siHIF-1alpha (* p < 0.01 Ad5-HIF-1alpha group vs. Ad5 group; ** p < 0.01 Ad5-si HIF-1alpha group vs. Ad5 group). (C) In the Ad5-HIF-1alpha group, the growth of cells was promoted after blockade of SOCS1 by Ad5-siSOCS1 (* p < 0.01 Ad5- HIF-1alpha/siSOCS1 group vs. Ad5-HIF-1alpha group). (D) In the Ad5-si HIF-1alpha group, the growth of cells was slowed after co-transfection with SOCS1 (* p < 0.05 Ad5-siHIF-1alpha/SOCS1 group vs. Ad5-siHIF-1alpha group). (E) In the Ad5-HIF-1alpha group, the growth of cells was slowed from day 5 to day 8 as the growth curve moved right after co-transfection with SOCS1 (* p < 0.05 Ad5-HIF-1alpha group vs. Ad5-HIF-1alpha/SOCS1 group).

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