Table 1 65 genes upregulated by HIF-1alpha more than 2.0-fold in three pairwise comparisons
From: The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells
UniGeneID | Gene name | Gene Symbol | Fold change(ratio ≥ 2) | ||
|---|---|---|---|---|---|
| Â | Â | Â | Ad5-HIF-1alpha/Ad5 | Ad5-siHIF-1alpha/Ad5 | Hypoxia/normoxia |
Immune response | |||||
Hs.351812 | C-type lectin domain family 4, member C | CLEC4C | 12.99 | -9.66 | 17.54 |
Hs.190622 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | DDX58 | 5.28 | -3.12 | 4.77 |
Hs.163173 | interferon induced with helicase C domain 1 | IFIH1 | 3.73 | -2.07 | 4.15 |
Hs.529053 | complement component 3 | C3 | 2.29 | -2.10 | 3.17 |
Transport | |||||
Hs.655445 | chloride intracellular channel 2 | CLIC2 | 12.12 | -3.92 | 10.46 |
Hs.257352 | apolipoprotein L, 6 | APOL6 | 8.57 | -3.98 | 7.92 |
Hs.78036 | solute carrier family 6, member 2 (neurotransmitter transporter, noradrenalin) | SLC6A2 | 5.28 | -4.01 | 4.79 |
Hs.250083 | solute carrier family 9, member 2 (sodium/hydrogen exchanger) | SLC9A2 | 2.64 | -2.19 | 3.17 |
Hs.200738 | solute carrier family 38, member 6 | SLC38A6 | 2.46 | -2.94 | 2.86 |
Hs.42645 | solute carrier family 16, member 6 (monocarboxylic acid transporter 7) | SLC16A6 | 2.30 | -3.16 | 4.90 |
Hs.577463 | solute carrier family 41, member 2 | SLC41A2 | 2.32 | -4.23 | 5.19 |
Hs.658514 | solute carrier family 12, member 8 (potassium/chloride transporters) | SLC12A8 | 2.14 | -3.01 | 3.75 |
Hs.510939 | solute carrier family 12, member 6 | SLC12A6 | 2.12 | -2.01 | 3.41 |
Hs.288034 | solute carrier family 39, member 8 (zinc transporter) | SLC39A8 | 2.05 | -2.92 | 4.35 |
Hs.235782 | solute carrier organic anion transporter family member 4A1 | SLCO4A1 | 2.05 | -2.88 | 5.12 |
Signal transduction | |||||
Hs.592215 | insulin receptor substrate 4 | IRS4 | 6.96 | -5.79 | 5.13 |
Hs.20961 | G protein-coupled estrogen receptor 1 | GPER1 | 6.50 | -3.05 | 7.99 |
Hs.75199 | protein phosphatase 2, regulatory subunit B beta isoform | PPP2R5B | 3.48 | -2.51 | 6.70 |
Hs.145404 | phosphatidylinositol-specific phospholipase C X domain containing 3 | PLCXD3 | 3.40 | -4.91 | 3.46 |
Hs.497402 | leucine-rich repeat-containing G protein-coupled receptor 6 | LGR6 | 2.46 | -2.19 | 4.10 |
Hs.458414 | interferon induced transmembrane protein 1 | IFITM1 | 2.29 | -3.43 | 2.86 |
Hs.645475 | amphiregulin (schwannoma-derived growth factor) | AREG | 2.05 | -3.07 | 3.86 |
Cell adhesion/motility | |||||
Hs.143250 | tenascin C (hexabrachion) | TNC | 5.28 | -3.23 | 6.44 |
Hs.2375 | egf-like module containing, mucin-like, hormone receptor-like 1 | EMR1 | 3.48 | -3.31 | 4.57 |
Hs.415762 | lymphocyte antigen 6 complex, locus D | LY6D | 2.30 | -4.30 | 3.61 |
Hs.479439 | protocadherin 7 | PCDH7 | 2.00 | -3.29 | 2.70 |
Hs.2962 | S100 calcium binding protein P | S100P | 4.59 | -2.16 | 4.32 |
Hs.332012 | immunoglobulin superfamily, member 8 | IGSF8 | 2.00 | -2.47 | 2.85 |
Growth factors/cytokines | |||||
Hs.73793 | Vascular endothelial growth factor-A | VEGF-A | 6.76 | -3.98 | 15.40 |
Hs.437322 | tumor necrosis factor, alpha-induced protein 6 | TNFAIP6 | 6.96 | -4.75 | 12.17 |
Hs.635441 | insulin-like growth factor binding protein 5 | IGFBP5 | 4.83 | -4.45 | 9.80 |
Hs.517581 | heme oxygenase (decycling) 1 | HMOX1 | 2.64 | -2.73 | 4.58 |
Hs.505924 | high mobility group AT-hook 2 | HMGA2 | 2.63 | -2.83 | 2.09 |
Hs.234434 | hairy/enhancer-of-split related with YRPW motif1 | HEY1 | 2.60 | -2.15 | 3.89 |
Hs.570855 | platelet derived growth factor C | PDGFC | 2.26 | -3.21 | 4.37 |
Hs.497200 | phospholipase A2, group IVA | PLA2G4A | 2.14 | -2.55 | 6.67 |
Hs.114948 | cytokine receptor-like factor 1 | CRLF1 | 2.00 | -3.05 | 4.75 |
Hs.50640 | suppressor of cytokine signaling 1 | SOCS1 | 7.46 | -7.13 | 8.06 |
Transcription | |||||
Hs.501778 | tripartite motif-containing 22 | TRIM22 | 4.56 | -4.14 | 4.47 |
Hs.1706 | interferon regulatory factor 9 | IRF9 | 3.73 | -2.16 | 3.90 |
Hs.567641 | myocardin | MYOCD | 3.03 | -2.08 | 3.58 |
Hs.655904 | zinc finger protein 277 | ZNF277 | 2.13 | -2.74 | 2.37 |
Hs.200250 | cAMP responsive element modulator | CREM | 2.05 | -2.31 | 3.45 |
Inflammatory response | |||||
Hs.437322 | tumor necrosis factor, alpha-induced protein 6 | TNFAIP6 | 6.97 | -6.07 | 7.39 |
Hs.701982 | interleukin 1 receptor, type I | IL1R1 | 2.64 | -2.21 | 4.00 |
Hs.525572 | bradykinin receptor B1 | BDKRB1 | 2.48 | -2.51 | 2.99 |
Hs.534847 | complement component 4A (Rodgers blood group) | C4A | 2.16 | -2.03 | 2.66 |
Hs.196384 | prostaglandin-endoperoxide synthase 2 | PTGS2 | 2.07 | -2.96 | 3.05 |
Hs.81791 | tumor necrosis factor receptor superfamily member 11b | TNFRSF11B | 2.00 | -2.77 | 3.65 |
Hs.203717 | fibronectin 1 | FN1 | 2.31 | -2.57 | 3.84 |
Hs.654458 | interleukin 6 (interferon, beta 2) | IL6 | 5.29 | -2.27 | 6.10 |
Metabolic process | |||||
Hs.387367 | cytochrome P450, family 39, subfamily A, polypeptide 1 | CYP39A1 | 11.32 | -7.58 | 12.30 |
Hs.460260 | aldo-keto reductase family 1, member C1 | AKR1C1 | 9.85 | -3.45 | 8.47 |
Hs.567256 | aldo-keto reductase family 1, member C2 | AKR1C2 | 3.10 | -2.37 | 2.90 |
Hs.116724 | aldo-keto reductase family 1, member B10 | AKR1B10 | 3.03 | -2.10 | 2.83 |
Hs.78183 | aldo-keto reductase family 1, member C3 | AKR1C3 | 2.65 | -2.07 | 2.30 |
Hs.419240 | solute carrier family 2, member 1 | SLC2A14 | 2.60 | -2.91 | 3.22 |
Hs.419240 | solute carrier family 2, member 3 | SLC2A3 | 2.46 | -2.17 | 3.91 |
Hs.572518 | UDP-glucose dehydrogenase | UGDH | 2.00 | -2.77 | 3.14 |
Protein amino acid dephosphorylation | |||||
Hs.160871 | protein tyrosine phosphatase, receptor type, O | PTPRO | 3.25 | -2.31 | 4.20 |
Hs.43666 | protein tyrosine phosphatase type IVA, member 3 | PTP4A3 | 2.46 | -2.83 | 4.66 |
Hs.497822 | dual specificity phosphatase 10 | DUSP10 | 2.14 | -3.15 | 3.02 |
Other up-regulated gene expression | |||||
Hs.459265 | interferon stimulated exonuclease gene 20 kDa | ISG20 | 9.19 | -4.57 | 8.10 |
Hs.118633 | 2'-5'-oligoadenylate synthetase-like | OASL | 8.00 | -4.82 | 6.26 |
Hs.144873 | BCL2/adenovirus E1B 19 kDa interacting protein 3 | BNIP3 | 2.12 | -2.35 | 4.19 |