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Table 2 28 genes downregulated by HIF-1alpha more than 2.0-fold in three pairwise comparisons

From: The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells

UniGeneID

Gene name

Gene Symbol

Fold change(ratio ≥ 2)

   

Ad5-HIF-1alpha/Ad5

Ad5-siHIF-1alpha/Ad5

Hypoxia/normoxia

Transport

Hs.666728

Na+/H+ exchanger domain containing 1

NHEDC1

-27.86

9.86

-12.33

Hs.666367

potassium voltage-gated channel, Shal-related subfamily, member 3

KCND3

-16.00

6.13

-11.82

Hs.581021

signal-regulatory protein alpha

SIRPa

-4.93

3.10

-3.72

Hs.504317

solute carrier family 16, member 14 (monocarboxylic acid transporter 14)

SLC16A14

-4.59

2.46

-4.30

Hs.118695

potassium voltage-gated channel, subfamily G, member 1

KCNG1

-2.13

2.35

-3.17

Hs.158748

solute carrier family 35, member F3

SLC35F3

-2.06

2.76

-2.55

Hs.443625

collagen, type III, alpha 1

COL3A1

-2.29

2.16

-3.78

Transcription

Hs.458406

undifferentiated embryonic cell

transcription factor 1

KCNG1

-36.76

12.17

-45.69

Hs.511848

zinc finger protein 569

ZNF569

-12.13

7.61

-15.33

Hs.412196

intraflagellar transport 57 homolog

IFT57

-8.58

4.38

-7.36

Hs.533977

thioredoxin interacting protein

TXNIP

-5.28

3.10

-5.01

Hs.4779

GATA zinc finger domain containing 2B

GATAD2B

-3.48

2.31

-6.30

Hs.9521

zinc finger protein 92

ZNF92

-2.83

2.09

-3.19

Hs.490273

cAMP responsive element binding

protein3-like 2

CREB3L2

-2.07

2.00

-3.12

Hs.524248

zinc finger protein 362

ZNF362

-2.00

2.67

-4.78

Growth factors/cytokines

Hs.485572

suppressor of cytokine signaling 2

SOCS2

-6.06

3.06

-7.12

Hs.450230

insulin-like growth factor binding

protein 3

IGFBP3

-4.02

2.17

-5.73

Hs.8867

cysteine-rich, angiogenic inducer, 61

CYR61

-3.03

2.18

-3.77

Hs.289008

nuclear undecaprenyl pyrophosphate-

synthase 1 homolog

NUS1

-2.83

2.13

-4.01

Hs.699288

neural precursor cell expressed, developmentally down-regulated 9

NEDD9

-2.64

2.26

-2.57

Protein amino acid phosphorylation

Hs.370503

FYN binding protein (FYB-120/130)

FYB

-6.06

3.97

-4.71

Hs.460355

protein kinase C, beta 1

PRKCB1

-3.25

2.56

-4.30

Hs.390729

v-erb-a erythroblastic leukemia viral oncogene homolog 4

ERBB4

-2.46

2.11

-3.89

Hs.654491

receptor tyrosine kinase-like orphan receptor 1

ROR1

-2.47

2.32

-4.56

Hs.653377

insulin-like growth factor 1 receptor

IGF1R

-2.00

2.89

-3.11

Other down-regulated gene expression

Hs.606356

pleckstrin homology domain interacting protein

PHIP

-17.15

4.76

-10.03

Hs.567359

X-ray repair complementing defective repair in Chinese hamster cells 4

XRCC4

-8.00

6.21

-5.69

Hs.502182

brain-derived neurotrophic factor

BDNF

-2.30

2.14

-2.18