The role of mTOR and phospho-p70S6K in pathogenesis and progression of gastric carcinomas: an immunohistochemical study on tissue microarray

Table 5 Relationship between cytoplasmic P70S6K expression and clinicopathological features of gastric carcinomas

Clinicopathological features	N	Cytoplasmic P70S6K expression
		-	+	++	+++	PR(%)	P value
Age(years)							0.001
<65	158	108	37	13	0	31.6
≥65	236	129	78	26	3	45.3
Sex							0.161
male	273	162	76	32	3	40.7
Female	121	75	39	7	0	38.0
Tumor size(cm)							0.393
<4	199	117	58	22	2	41.2
≥4	195	120	57	17	1	38.5
Depth of invasion							0.747
T_is-1	197	117	59	19	2	40.6
T_2-4	197	120	56	20	1	39.5
Lymphatic invasion							0.739
-	247	150	73	21	3	39.3
+	147	87	42	18	0	40.8
Venous invasion							0.452
-	235	202	101	29	3	56.6
+	55	35	10	10	0	36.4
Lymph node metastasis							0.550
-	239	140	74	23	2	41.4
+	155	97	41	16	1	37.4
UICC staging							0.996
0-I	213	128	63	20	2	39.9
II-IV	181	109	52	19	1	39.8
Lauren classification							0.000
Intestinal type	209	96	81	30	2	54.1
Diffuse type	174	134	30	9	1	23.0
Nuclear P70S6K expression							0.000
-	188	153	28	7	0	18.6
+~+++	202	83	84	32	3	58.9

PR = positive rate; T_is = carcinoma in situ; T₁ = lamina propria and submucosa; T₂ = muscularis propria and subserosa; T₃ = exposure to serosa; T₄ = invasion into serosa; UICC = Union Internationale Contre le Cancer

ISSN: 1756-9966