The role of mTOR and phospho-p70S6K in pathogenesis and progression of gastric carcinomas: an immunohistochemical study on tissue microarray

Table 6 Relationship between nuclear P70S6K expression and clinicopathological features of gastric carcinomas

Clinicopathological features	N	Nuclear P70S6K expression
		-	+	++	+++	PR(%)	P value
Age(years)							0.042
<65	165	86	49	20	10	47.9
≥65	39	102	74	53	10	57.3
Sex							0.172
male	282	127	85	54	16	55.0
Female	122	61	38	19	4	50
Tumor size(cm)							0.001
<4	210	86	59	52	13	59.0
≥4	194	102	64	21	7	47.4
Depth of invasion							0.000
T_is-1	208	81	61	53	13	61.1
T_2-4	196	107	62	20	7	45.4
Lymphatic invasion							0.171
-	257	114	77	54	12	55.6
+	147	74	46	19	8	49.7
Venous invasion							0.611
-	340	164	98	65	13	51.8
+	64	24	25	8	7	62.5
Lymph node metastasis							0.000
-	248	102	72	59	15	58.9
+	156	86	51	14	5	44.9
UICC staging							0.002
0-I	213	93	64	53	13	61.0
II-IV	181	95	59	20	7	47.5
Lauren classification							0.000
Intestinal type	221	76	70	58	17	65.6
Diffuse type	172	105	52	12	3	40.0

PR = positive rate; T_is = carcinoma in situ; T₁ = lamina propria and submucosa; T₂ = muscularis propria and subserosa; T₃ = exposure to serosa; T₄ = invasion into serosa; UICC = Union Internationale Contre le Cancer

ISSN: 1756-9966