Table 1 Correlation between RASSF1A promoter methylation and clinicopathological index in NPC
| Â | No. of patient | Promoter methylation status | Frequency of methylationincidence | Â | |
|---|---|---|---|---|---|
| Â | Â | Methylated | Unmethylated | Â | Â |
Gender | Â | Â | Â | Â | NS |
   Male | 22 | 17 | 5 | 77.27% |  |
   Female | 16 | 10 | 6 | 62.50% |  |
Age | Â | Â | Â | Â | NS |
   ≤50 | 17 | 14 | 3 | 82.35% |  |
   >50 | 21 | 13 | 8 | 61.90% |  |
Histological subtype | Â | Â | Â | Â | p = 0.047 |
   poorly differentiated | 27 | 22 | 5 | 81.48% |  |
   Well-differentiated | 11 | 5 | 6 | 45.45% |  |
Stage | Â | Â | Â | Â | NS |
   I and II | 13 | 9 | 4 | 69.23% |  |
   III and IV | 25 | 18 | 7 | 72.00% |  |
Lymph node | Â | Â | Â | Â | NS |
   Positive | 29 | 22 | 7 | 75.86% |  |
   Negative | 9 | 5 | 4 | 55.56% |  |
Distance metastasis | Â | Â | Â | Â | NS |
   Positive | 5 | 4 | 1 | 80.00% |  |
   Negative | 33 | 23 | 10 | 69.70% |  |