Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis

Table 3 Univariate Cox regression analysis for disease-free survival

Variable	Hazard Ratio	95% Confidence Interval		P value
		Lower limit	Upper limit
Age (< 55 years vs ≥ 55 years)	0.80	0.50	1.27	0.34
Gender (male vs female)	1.02	0.60	1.73	0.95
Edmondson grade (I vs II)	1.25	0.72	2.17	0.43
Edmondson grade (I vs III – IV)	1.08	0.50	2.30	0.85
HbsAg (absent vs present)	1.02	0.58	1.80	0.94
HCV (absent vs present)	2.11	0.97	4.60	0.061
AFP level (< 100 ng/ml vs ≥ 100 ng/ml)	1.19	0.76	1.86	0.45
Liver cirrhosis (absent vs present)	1.14	0.73	1.78	0.57
Tumor size (< 5 cm vs ≥ 5 cm)	1.30	0.82	2.04	0.26
Tumor stage (I vs II)	1.10	0.64	1.89	0.72
Tumor stage (I vs III – IV)	2.22	1.27	3.87	0.0049
NNMT (low vs high)	1.72	1.10	2.70	0.018

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