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Figure 1 | Journal of Experimental & Clinical Cancer Research

Figure 1

From: Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells

Figure 1

Screening of OSCC cell lines in order to obtain a suitable cell line model for inducing MErT. (A) Of the 7 OSCC cell lines, KB, KOSCC-25B, Ca9-22, and SCC-15 showed constitutively activated phosphorylated Akt (p-Akt). Of these four lines, only KB and KOSCC-25B showed low or negative expression of E-cadherin. (B) Methylation specific-PCR: PCR products were detected in both KB and KOSCC-25B with unmethylation-specific primer pairs, not methylation-specific ones. M, DNA ladder; lane 1, MDA-MB-231; lane 2, MCF-7; lane 3, KB; lane 4, KOSCC-25B.

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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