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Figure 2 | Journal of Experimental & Clinical Cancer Research

Figure 2

From: Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells

Figure 2

Effects of PIA treatment on Akt and Akt-related signaling molecules. (A) P-Akt level in KB and KOSCC-25B cells was significantly lower after 5 μM PIA treatment for 24 hours. However, Akt1/2 and ILK (upstream molecules of Akt) did not show any change after PIA treatment. (B) Inhibition of Akt activity by PIA induced downregulation of p50 and p-p65 in KB and KOSCC-25B cells, but it did not affect phosphorylation of JNK, p38, and ERK.

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