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Figure 3 | Journal of Experimental & Clinical Cancer Research

Figure 3

From: Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells

Figure 3

Effects of Akt inhibition on Snail1, SIP-1/ZEB-2, and Twist expression and localization. (A) Downregulation of Snail and Twist was detected in KB and KOSCC-25B cells by immunoblot and RT-PCR analysis. In contrast, inhibition of Akt activity by PIA did not induce any changes in SIP-1/ZEB-2 mRNA and protein expression. (B) A shift from the nucleus to the cytoplasm of Snail and Twist in KOSCC-25B cells was detected by immunofluorescence analysis.

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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