From: Effect of hypoxia-inducible factor-1α on transcription of survivin in non-small cell lung cancer
HIF-1α protein | Survivin protein | ||||||
---|---|---|---|---|---|---|---|
Clinical Pathology | N | positive | positive rate (%) | p | positive | positive rate (%) | p |
sex | |||||||
male | 94 | 56 | 59.6 | >0.05 | 79 | 84.0 | >0.05 |
female | 26 | 14 | 53.8 | 19 | 73.1 | ||
age | |||||||
≤60 | 67 | 41 | 61.2 | >0.05 | 52 | 77.6 | >0.05 |
>60 | 53 | 29 | 54.7 | 46 | 86.8 | ||
degree of differentiation | |||||||
high | 45 | 19 | 42.2 | <0.01 | 31 | 68.9 | <0.01 |
moderate | 46 | 29 | 63.0 | 39 | 84.8 | ||
low or undifferentiation | 29 | 22 | 75.9 | 28 | 96.6 | ||
clinical stage | |||||||
I~II | 43 | 18 | 41.9 | <0.01 | 29 | 72.1 | <0.01 |
III | 77 | 52 | 67.5 | 69 | 87.0 | ||
lymph nodes metastasis | |||||||
yes | 73 | 49 | 67.1 | <0.01 | 66 | 90.4 | <0.01 |
no | 47 | 21 | 44.7 | 32 | 68.1 | ||
Survivin Positive** | 98 | 63 | 90(63/70) | = 0.005 |