Reduction of serum IGF-I levels in patients affected with Monoclonal Gammopathies of undetermined significance or Multiple Myeloma. Comparison with bFGF, VEGF and K-ras gene mutation

Table 3 K-ras gene status and response to therapy

Group	K12-ras gene mutation/total (%)	Positive therapy response (%)		P Value
		Mutant	Wild type
Controls	0/75 (0)	__	__	__
MGUS	1/66 (1.5)	__	__	__
MM	20/73 (27.4)	26.9	58.3	0.01

Statistical significance for K12-ras gene mutation: Control vs MGUS p = 0.95, Control vs MM p = 0.0001, MGUS vs MM p < 0.0001, Positive therapy response: minor response and no change disease (see Methods).

ISSN: 1756-9966