Figure 2

Kaplan-Meier cumulative survival analysis according to staining for nuclear and cytoplasmic HIF-1α, VEGF-A and VEGF-C. The log-rank test showed significantly shorter overall survival in patients with tumors showing low nHIF-1α (p = 0.005) (A) and low pVEGF-C (p = 0.008) (D). The 5-year survival rate was 32% for patients whose tumors showed low nHIF-1α vs. 65% for patients whose tumors showed high nHIF-1α (A); and 40% for patients whose tumors showed low pVEGF-C vs. 61% for patients whose tumors showed high pVEGF-C (D). The log-rank test showed significantly shorter overall survival in patients with tumors showing high cHIF-1α (p = 0.018) (B) and high dVEGF-A (p = 0.024) (C). The 5-year survival rate was 60% for patients whose tumors showed low cHIF-1α vs. 40% for patients whose tumors showed high cHIF-1α (B); and 59% for patients whose tumors showed low dVEGF-A vs. 40% for patients whose tumors showed high dVEGF-A (C).