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Table 2 Relation of HIF-1α, VEGF-A and VEGF-C to clinicopathologic parameters

From: Hypoxia inducible factor-1α correlates with vascular endothelial growth factor A and C indicating worse prognosis in clear cell renal cell carcinoma

  

Nuclear grade1

P value

Tumor size (cm)1

p value

Ki67 (%)1,2

P value

Pathologic stage1

P value

  

1,2

3,4

 

< 7

≥ 7

 

low

high

 

1

2,3,4,

 

HIF-1α

nHIF-1α

49.5

39

0.006

48.6

43.6

0.057

43.9

48.1

0.134

48.1

44.5

0.165

(%)

 

(16.3–82.3)

(19.2–72.6)

 

(27.9–73.9)

(16.3–82.3)

 

(16.3–72.4)

(21.2–82.3)

 

(27.9–73.9)

(16.3–82.3)

 
 

cHIF-1α

11.4

18.7

0.006

11.3

17.5

0.009

14.6

11.6

0.246

11.4

16.6

0.023

  

(1.4–75)

(5.2–59.5)

 

(1.4–59.5)

(2.9–75)

 

(4.3–75)

(1.4–46.5)

 

(1.4–42.6)

(2.9–75)

 

VEGF-A

pVEGF-A

15

12.5

0.307

15

7.5

0.173

12.5

12.7

0.658

12.1

17.5

0.682

(%)

 

(0.00–94)

(0–75)

 

(0–94)

(0–75)

 

(0–94)

(0–75)

 

(0–94)

(0–75)

 
 

dVEGF-A

6.7

30

<0.001

6.7

16.7

0.015

10.6

10

0.652

6.3

11.7

0.027

  

(0–92.5)

(0–90)

 

(0–67.5)

(0–92.5)

 

(0–92.5)

(0–83.3)

 

(0–76.7)

(0–92.5)

 

VEGF-C

pVEGF-C

65

14

<0.001

64.2

27.9

0.007

45

55

0.913

61.3

33.3

0.042

(%)

 

(0–100)

(0–92.5)

 

(0–100)

(0–100)

 

(0–100)

(0–100)

 

(0–100)

(0–100)

 
 

dVEGF-C

18.5

37

0.004

18

37.1

0.007

25

26.3

0.516

20

30

0.109

  

(0–100)

(0–100)

 

(0–100)

(0–100)

 

(0–100)

(0–100)

 

(0–100)

(0–100)

 
  1. 1Mann-Whitney U-test; median (range); 2cut-off is mean