Grade | Definition | Underlying Methodology |
---|---|---|
High | Further research is very unlikely to change our confidence in the estimate of effect | RCT or meta-analysis |
Moderate | Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate | Downgraded RCTs or upgraded observational studies |
Low | have an important impact on our confidence in the estimate of effect an its likely to change the estimate | Well-done observational studies with control groups |
Very low | Any estimate of effect is very uncertain | Others (e.g., case reports or case series) |