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Table 1 Quality of the quality evidence, definitions and underlying methodology
| Grade | Definition | Underlying Methodology |
|---|---|---|
| High | Further research is very unlikely to change our confidence in the estimate of effect | RCT or meta-analysis |
| Moderate | Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate | Downgraded RCTs or upgraded observational studies |
| Low | have an important impact on our confidence in the estimate of effect an its likely to change the estimate | Well-done observational studies with control groups |
| Very low | Any estimate of effect is very uncertain | Others (e.g., case reports or case series) |
