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Table 2 Strength of recommendations and implication to quality of evidence.

From: Brachytherapy for cervix cancer: low-dose rate or high-dose rate brachytherapy – a meta-analysis of clinical trials

Recommendation or statement Description in GRADE approach Interpretation
Strong recommendation We recommend (should) 1. Most individuals should receive the intervention, assuming that they have been informed about and have understood its benefits, harms and burden.
   2. The recommendation could unequivocally be used for policy making.
Weak recommendation We suggest (might) 1. Uncertainty about the relative importance of the benefits and downsides to those affected, or differences in how important they are to different people, which could affect the balance between the benefits versus harms and burden
   2. Doubt about the recommendation could be use for policy making