Figure 5From: The effect of high frequency steep pulsed electric fields on in vitro and in vivo antitumor efficiency of ovarian cancer cell line skov3 and potential use in electrochemotherapyMicrophotos of SKOV3 cells under TEM observation. 5A: Abundant mitochondria and nucleoli with increased karyoplasm ratio in non-exposure cells. (TEM × 3500). 5B: In response to SPEF exposure (1 kHz), SKOV3 plasma membrane and karyotheca was disintegrated, subcellular organelles such as mitochondria, endoplasmic reticulum and nucleus were cavitated and swollen. (TEM × 3500). 5C: Typical characteristic of apoptosis was further induced by SPEF exposure (5 kHz). (TEM × 10000).Back to article page