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Figure 2 | Journal of Experimental & Clinical Cancer Research

Figure 2

From: Role of hepatitis B surface antigen in the development of hepatocellular carcinoma: regulation of lymphoid enhancer-binding factor 1

Figure 2

Intracellular expression and distribution of HBsAg and LEF-1 in liver tissue sections. HBsAg (A, C, E) and LEF-1 protein (B, D, F) expression in liver tissues sections was determined by immunohistochemical staining using anti-HBsAg monoclonal antibody and anti-LEF-1 rabbit polyclonal antibody respectively (400× magnification). HBsAg and LEF-1 expression and cellular distribution were studied and compared in tumor tissues (T) (A, B), peritumor tissues (pT) (C, D) and normal liver tissues (NL) (E, F). As shown, HBsAg was expressed at lower level in tumor tissues compared to that of peritumor tissues, and LEF-1 was found exclusively in the nucleus in tumor tissues, whereas it was mainly detected in the cytoplasm in peritumor tissues.

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