Table 3 Selected genes with significantly altered expression in all three biliary cancer subtypes with the fold-change (Δ) in expression
Δ GB | Δ Intra | Δ Extra | Gene Symbol | Gene Title | Chromosomal Location | Functional Pathway |
|---|---|---|---|---|---|---|
58 | 11 | 11 | RRM2 | ribonucleotide reductase M2 polypeptide | chr2p25-p24 | Nucleotide metabolism |
41 | 6 | 10 | PTTG1 | pituitary tumor-transforming 1 | chr5q35.1 | Cell cycle |
26 | 9 | 7 | TYMS | thymidylate synthetase | chr18p11.32 | Nucleotide metabolism |
19 | 4 | 5 | CDC2 | Cell division cycle 2, G1 to S and G2 to M | chr10q21.1 | Cell cycle |
18 | 4 | 7 | CCNB2 | cyclin B2 | chr15q22.2 | Cell cycle |
12 | 3 | 4 | RACGAP1 | Rac GTPase activating protein 1 | chr12q13.12 | S1P Signaling |
6 | 5 | 4 | SHMT2 | serine hydroxymethyltransferase 2 (mitochondrial) | chr12q12-q14 | Amino acid metabolism |
3 | 3 | 3 | PPAT | phosphoribosyl pyrophosphate amidotransferase | chr4q12 | Purine metabolism |
3 | 3 | 5 | MCM6 | MCM6 minichromosome maintenance deficient 6 | chr2q21 | Cell cycle |
3 | 3 | 3 | GMPS | guanine monphosphate synthetase | chr3q24 | Nucleotide metabolism |
2 | 2 | 2 | RPS19 | ribosomal protein S19 | chr19q13.2 | Ribosomal protein |
2 | 3 | 2 | CBX3 | chromobox homolog 3 | chr7p15.2 | Circadian exercise |
2 | 3 | 2 | EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | chr7p22 | Translation factor |
2 | 2 | 2 | EPRS | glutamyl-prolyl-tRNA synthetase | chr1q41-q42 | Glutamate metabolism |
2 | 2 | 2 | PARP1 | poly (ADP-ribose) polymerase family, member 1 | chr1q41-q42 | Apoptosis |
2 | 2 | 2 | SNRPD2 | small nuclear ribonucleoprotein D2 polypeptide 16.5 kDa | chr19q13.2 | mRNA processing |
-2 | -2 | -2 | UBE2G2 | ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog) | chr21q22.3 | Proteolysis |
-2 | -2 | -2 | HNRPH1 | Heterogeneous nuclear ribonucleoprotein H1 | chr5q35.3 | mRNA processing |
-2 | -3 | -3 | SUI1 | putative translation initiation factor | chr17q21.2 | Translation factor |
-3 | -4 | -3 | RBM5 | RNA binding motif protein 5 | chr3p21.3 | mRNA processing |
-3 | -2 | -2 | SFRS5 | splicing factor, arginine/serine-rich 5 | chr14q24 | mRNA processing |
-3 | -3 | -3 | BCL2L2 | BCL2-like 2 | chr14q11.2-q12 | Apoptosis |
-4 | -10 | -7 | CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | chr11p15.5 | G1 to S cell cycle |
-4 | -8 | -5 | ZNF423 | zinc finger protein 423 | chr16q12 | TGF-β signaling |
-4 | -3 | -3 | ACACB | acetyl-Coenzyme A carboxylase beta | chr12q24.11 | Fatty acid synthesis |
-4 | -4 | -3 | RBM5 | RNA binding motif protein 5 | chr3p21.3 | mRNA processing |
-5 | -7 | -5 | PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | chr7q22 | G protein signaling |
-5 | -4 | -4 | ACACB | acetyl-Coenzyme A carboxylase beta | chr12q24.11 | Fatty acid synthesis |
-6 | -4 | -4 | ITGA7 | integrin, alpha 7 | chr12q13 | Cellular adhesion |
-6 | -7 | -5 | RGS2 | regulator of G-protein signaling 2, 24 kDa | chr1q31 | Calcium regulation |
-6 | -9 | -5 | KLF9 | Kruppel-like factor 9 | chr9q13 | Circadian exercise |
-7 | -7 | -7 | RPS6KA2 | ribosomal protein S6 kinase, 90 kDa, polypeptide 2 | chr6q27 | Ribosomal protein |
-7 | -15 | -10 | ANK2 | ankyrin 2, neuronal | chr4q25-q27 | Ribosomal protein |
-8 | -5 | -6 | ACACB | acetyl-Coenzyme A carboxylase beta | chr12q24.11 | Fatty acid synthesis |
-10 | -4 | -4 | MYOM1 | myomesin 1 (skelemin) 185 kDa | chr18p11.32-p11.31 | Muscle contraction |
-11 | -13 | -8 | ITGA7 | integrin, alpha 7 | chr12q13 | Cellular adhesion |
-13 | -27 | -14 | CDKN1C | Cyclin-dependent kinase inhibitor 1C (p57, Kip2) | chr11p15.5 | G1 to S cell cycle |
-61 | -27 | -26 | ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | chr15q21.3 | Metabolism/Biosynthesis |
-67 | -20 | -7 | CNN1 | calponin 1, basic, smooth muscle | chr19p13.2-p13.1 | Muscle contraction |
-85 | -51 | -18 | CES1 | carboxylesterase 1 | chr16q13-q22.1 | Irinotecan pathway |
-102 | -30 | -24 | DES | desmin | chr2q35 | Muscle contraction |